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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Urology Research

Browse the latest research summaries in the field of urology for spinal cord injury patients and caregivers.

Showing 51-60 of 407 results

Spinal Cord InjuryUrology

Editorial Comment: Prediction Model for Neurogenic Bladder Recovery One Year After Traumatic Spinal Cord Injury

Int Braz J Urol, 2023 • November 1, 2023

El Sammak S. et al. have aimed to build a prediction model for neurogenic lower urinary tract dysfunction (NLUTD) recovery 1 year after traumatic spinal cord injury (SCI). This prediction model may ul...

KEY FINDING: Sacral sensation, American Spinal Injury Association (ASIA) impairment score, bowel function at baseline, voluntary sphincter contraction, anal sensation, S1 motor scores, and the number of days in the rehabilitation facility were identified as predictors of bladder recovery, with a discriminative capacity of 90.5%.

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UrologyNeurologyBiomedical

Novel phenotype characterization utilizing electrical impedance myography signatures in murine spinal cord injury neurogenic bladder models

Scientific Reports, 2023 • November 4, 2023

Our SCI animal model resulted in NB phenotypes in the SCI group with evidence of an increased ratio of bladder to whole body weight and constant dribbling voiding pattern in voiding spot assays. Multi...

KEY FINDING: SCI mice had greater bladder-to-body weight ratio (p < 0.0001), greater collagen deposition (p = 0.009), and greater smooth-muscle-myosin-heavy-chain isoform A/B ratio (p < 0.0001).

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Spinal Cord InjuryUrologyBioinformatics

Integrated omics analysis unveils a DNA damage response to neurogenic injury

bioRxiv, 2023 • December 10, 2023

This study investigates the molecular changes in the bladder following spinal cord injury (SCI) in rats and the effect of inosine treatment using multi-omics analysis. The research identifies key path...

KEY FINDING: SCI regulates canonical pathways associated with protein synthesis, neuroplasticity, wound healing, and neurotransmitter degradation.

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UrologyEndocrinology

Penile prosthesis in the medically complex patient: a narrative review

Translational Andrology and Urology, 2023 • December 21, 2023

Penile implant surgery is a safe and effective treatment for erectile dysfunction but requires careful consideration in medically complex patients. Preoperative diagnostics and counseling are crucial ...

KEY FINDING: Patients with spinal cord injuries may benefit from penile implants for both ED and urinary symptoms, but require careful consideration of dexterity and sensation.

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Spinal Cord InjuryUrology

Management of neurogenic bladder in patients with spinal cord injuries/disorders and end stage renal disease: a case series

Spinal Cord Series and Cases, 2024 • February 27, 2024

This case series presents eleven unique cases of neurogenic lower urinary tract dysfunction (NLUTD) with associated end-stage renal disease (ESRD) in patients with spinal cord injuries/disorders (SCI/...

KEY FINDING: Determining a patient's baseline urine production is crucial, especially in those with ESRD, to avoid complications from assuming anuria.

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UrologyPharmacology

Pathophysiology of Overactive Bladder and Pharmacologic Treatments Including β3-Adrenoceptor Agonists -Basic Research Perspectives-

International Neurourology Journal, 2024 • February 29, 2024

This review article explores the pathophysiology of overactive bladder (OAB), highlighting the neurogenic, myogenic, and urothelial mechanisms involved in its development. It discusses how afferent si...

KEY FINDING: OAB pathophysiology involves neurogenic, myogenic, and urothelial mechanisms, with afferent noises triggering urgency-related detrusor contractions.

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UrologyHealthcareResearch Methodology & Design

Inappropriate placement of urinary catheters into the ureter: A case report and literature review

Medicine, 2024 • April 12, 2024

This article presents a case of ureteral misplacement of a suprapubic catheter (SPC) in an 82-year-old man with a history of prostate cancer and stroke, who developed septic shock due to the misplacem...

KEY FINDING: Female gender, neurologic conditions, and long-term catheterization were identified as predominant risk factors for ureteral cannulation.

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Spinal Cord InjuryUrologyOncology

Clinical characteristics and molecular mechanisms underlying bladder cancer in individuals with spinal cord injury: a systematic review

BMC Urology, 2024 • April 1, 2024

This systematic review highlights the increased risk of bladder cancer in patients with spinal cord injury (SCI), addressing both clinical characteristics and underlying molecular mechanisms. The revi...

KEY FINDING: The incidence and mortality rates of bladder cancer are higher in spinal cord injury (SCI) patients compared to the general population.

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UrologyEndocrinologyGenetics

SRS 16-86 promotes diabetic nephropathy recovery by regulating ferroptosis

Experimental Physiology, 2024 • May 2, 2024

This study investigates the role of ferroptosis in diabetic nephropathy (DN) and the efficacy of the ferroptosis inhibitor SRS 16-86 in DN recovery. The findings show that SRS 16-86 promotes renal fun...

KEY FINDING: SRS 16-86 could improve the recovery of renal function after DN by upregulating glutathione peroxidase 4, glutathione and system xc−light chain and by downregulating the lipid peroxidation markers and 4-hydroxynonenal.

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Spinal Cord InjuryUrology

Risk factors of video urodynamics and bladder management for long‑term complications in patients with chronic spinal cord injury

Scientific Reports, 2024 • June 14, 2024

This study analyzes long-term urological complications in 864 SCI patients with a mean 15.6-year follow-up, assessing complications and utilizing multivariate logistic regression for risk evaluation. ...

KEY FINDING: A contracted bladder identified in VUDS is associated with long-term urological complications in SCI.

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