Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 1-10 of 639 results
Exp Neurol, 2012 • May 1, 2012
Myelin-associated inhibitors of axon growth, including Nogo, MAG and OMgp, have been the subject of intense research to promote axonal repair after spinal cord injury. Different definitions of axon sp...
KEY FINDING: Genetic analysis using Nogo knockout mice produced different outcomes ranging from robust, suggestive, to no regeneration, which have led to a major controversy regarding Nogo’s role in axon regeneration.
J Biomed Mater Res A, 2011 • September 1, 2011
The study investigates the use of PLG bridges to deliver VEGF and FGF-2 to promote angiogenesis and nerve growth after spinal cord injury. The method of protein incorporation affects release, with enc...
KEY FINDING: Encapsulation of proteins within microspheres resulted in slower protein release compared to mixing proteins directly into the bridge material.
J Neural Eng, 2011 • August 1, 2011
This study investigated the possibility of using aligned, electrospun fibers loaded with a metabolic inhibitor (6AN) to selectively target astrocytes while allowing nerve growth. While it was difficul...
KEY FINDING: 6AN release from the fiber substrates occurred continuously over two weeks.
Muscle Nerve, 2011 • October 1, 2011
This study used a genome-wide association study (GWAS) approach to identify genetic susceptibility loci in patients with severe statin myopathy compared to a statin-tolerant group. Replication studies...
KEY FINDING: Three SNPs (rs9342288, rs1337512 and rs3857532) in the EYS gene on chromosome 6 are suggestively associated with risk for severe statin myopathy.
Frontiers in Molecular Neuroscience, 2011 • September 23, 2011
This mini-review discusses the potential of deoxyribozymes as a therapeutic approach for central nervous system (CNS) disorders, particularly spinal cord injuries (SCIs). Deoxyribozymes are catalytic ...
KEY FINDING: Deoxyribozymes can be designed to cleave specific mRNA targets, preventing protein translation and potentially altering disease pathways.
British Journal of Pharmacology, 2012 • May 1, 2012
This study investigates the effect of ethyl pyruvate on spinal cord repair in a rat model of SCI, focusing on its impact on astrogliosis, neuroinflammation, neuronal survival, and axonal regeneration....
KEY FINDING: Ethyl pyruvate treatment improved locomotor recovery in rats after spinal cord injury, as evidenced by BBB scoring, horizontal-ladder test, and foot-print analyses.
J. Cell. Mol. Med., 2012 • August 1, 2012
This study demonstrated neuroprotective effects of Erythropoietin (EPO) in a mouse model of ischaemic spinal cord injury (SCI). EPO treatment improved neurological function and reduced motor neuron lo...
KEY FINDING: Erythropoietin-treated mice with complete paralysis demonstrated significant improvement of neurological function between day 2 and 7, compared to saline-treated mice with complete paralysis.
Drug Discov Today, 2012 • August 1, 2012
This review provides an overview of traumatic CNS injuries and discusses emerging pharmacological options, highlighting therapies that modulate mTOR signaling. The mTOR pathway plays an important role...
KEY FINDING: Activation of the mTOR pathway can reduce neuronal death and promote repair and regeneration in the CNS.
Cell Tissue Res., 2012 • July 1, 2012
The review focuses on the role of RhoA inhibition in promoting axonal plasticity and functional recovery after CNS injury, particularly spinal cord injury (SCI). It highlights how blocking RhoA activa...
KEY FINDING: Ibuprofen inhibits RhoA activation, enhancing axonal sprouting/regeneration.
J Control Release, 2012 • August 10, 2012
This study introduces drug-eluting microfibrous patches as a platform for the local delivery of rolipram to treat spinal cord injuries in rats. The patches were designed to control the release of roli...
KEY FINDING: Low-dose rolipram patches led to significant improvements in functional outcomes, with higher Martinez forelimb open-field scores compared to all other groups.