Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 1-10 of 702 results
BMC Developmental Biology, 2012 • August 25, 2012
This study investigates positional information during zebrafish caudal fin regeneration by examining bony ray bifurcations after repeated amputations at different locations. The results show that repe...
KEY FINDING: Repeated amputations performed at a long distance from the bifurcation do not change its proximal-distal position in the regenerated fin, while consecutive amputations near the bifurcation induce a positional reset and progressively shift its position distally.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2013 • January 1, 2013
This study established a novel rat SCI model involving spinal cord transection and spine shortening to ensure complete axonal transection. The results indicated that axonal regeneration was inhibited ...
KEY FINDING: Uncoordinated movements of the hind limbs were observed at 4 weeks after surgery, but coordinated movements were not observed by the end of the 12-week experiment.
PLoS ONE, 2013 • March 4, 2013
The study introduces a robust zebrafish primary neuron culture system for functional nerve growth and guidance assays. Distinct classes of central nervous system neurons were dissociated and plated on...
KEY FINDING: Zebrafish neurons in culture extend axons with dynamic growth cones, exhibiting an average extension rate of 21.461.2 mm/hr for spinal cord neurons.
PLoS ONE, 2013 • June 19, 2013
The study demonstrates that nestin-expressing cells in the sciatic nerve can differentiate into various cell types and contribute to nerve fiber growth in a 3D culture system. The research shows that ...
KEY FINDING: Nestin-expressing cells in the sciatic nerve have the ability to form spheres and differentiate into neurons, glia, keratinocytes, and smooth muscle cells in vitro.
PLoS ONE, 2014 • January 20, 2014
This study utilizes a high-density microarray to profile the temporal transcriptome dynamics during spinal cord regeneration in zebrafish, identifying 3842 differentially expressed genes. Cluster anal...
KEY FINDING: A total of 3842 genes were found to be differentially expressed during spinal cord regeneration, with maximum numbers of genes differentially expressed at 7 days post injury.
JOURNAL OF NEUROTRAUMA, 2014 • August 1, 2014
The MIASCI draft standard has been proposed to capture SCI experimental details, including the investigator, organism, behavior, surgery, perturbagens, histology, immunohistochemistry, imaging, biomat...
KEY FINDING: Transparent reporting standards for experiments using animal models of human SCI aim to reduce inherent bias and increase experimental value.
Neural Development, 2014 • May 22, 2014
This study investigates the transcriptome-wide response to spinal cord injury in regenerative (R-) and non-regenerative (NR-) stages of Xenopus laevis to identify mechanisms underlying successful rege...
KEY FINDING: Regenerative tadpoles showed extensive transcriptome changes at 1 day after injury, while non-regenerative froglets showed changes at 6 days after injury, indicating different kinetics in the responses.
Journal of Visualized Experiments, 2014 • May 21, 2014
This video article details a method for performing spinal cord transections on larval zebrafish to study regeneration. Unlike mammals, zebrafish exhibit robust recovery after spinal cord injury. The p...
KEY FINDING: The presented method allows for high throughput spinal cord transections in larval zebrafish with low mortality and high reproducibility.
Front Biol (Beijing), 2014 • February 1, 2014
This review examines the role of surgical decompression in treating acute spinal cord injury (SCI), considering both clinical and animal studies. The timing of surgery is a key factor, with evidence s...
KEY FINDING: Early surgical decompression (within 24 hours of injury) may lead to better neurological outcomes, reduced complications, and shorter hospital stays compared to delayed surgery.
Neural Regen Res, 2013 • December 1, 2013
This study investigates the role of PD-L1 in the pathogenesis of experimental allergic encephalomyelitis (EAE), a mouse model for multiple sclerosis (MS). The researchers induced EAE in C57BL/6J mice ...
KEY FINDING: PD-L1 expression was significantly increased in the spinal cord of EAE mice compared to control mice, as shown by immunohistochemical staining.