Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 1-10 of 904 results
Tissue Eng Regen Med, 2022 • June 29, 2022
3D bioprinting is a new and powerful approach for SCI regeneration. Good mechanical properties of scaffolds can guide axon regeneration before being completely biodegraded, and be powerful enough to w...
KEY FINDING: 3D bioprinting is a promising method for producing complex microstructures to treat SCI.
J. R. Soc. Interface, 2011 • April 27, 2011
This study introduces a novel application of genipin-cross-linked casein (GCC) to fabricate biodegradable conduits for peripheral nerve repair, capitalizing on the biocompatibility and non-toxicity of...
KEY FINDING: GCC conduits are non-toxic and support Schwann cell survival and outgrowth, essential for nerve regeneration.
Acta Biomater, 2011 • July 1, 2011
This study developed electrically conductive nanowire surfaces using PCL coated with PPy to enhance neural stem cell (NSC) adhesion, proliferation, and differentiation, addressing the need for improve...
KEY FINDING: Polypyrrole (PPy) coating significantly reduces the electrical resistivity of PCL nanowires, creating a functional surface for electrical stimulation.
PLoS ONE, 2011 • May 18, 2011
This study evaluated the neurorigenerative properties of RADA16-4G-BMHP1 SAP by injecting the scaffold immediately after contusion in the rat spinal cord, then evaluating the early effects by semi-qua...
KEY FINDING: The functionalized SAP, RADA16-4G-BMHP1, induced a general upregulation of GAP-43, trophic factors and ECM remodelling proteins at 7 days after lesion.
J Biomed Mater Res A, 2011 • September 1, 2011
The study investigates the use of PLG bridges to deliver VEGF and FGF-2 to promote angiogenesis and nerve growth after spinal cord injury. The method of protein incorporation affects release, with enc...
KEY FINDING: Encapsulation of proteins within microspheres resulted in slower protein release compared to mixing proteins directly into the bridge material.
Biomaterials, 2011 • September 1, 2011
This study investigates the use of aligned poly-L-lactic acid (PLA) microfibers to promote axonal regeneration after complete spinal cord transection in rats. The researchers found that aligned microf...
KEY FINDING: Aligned poly-L-lactic acid (PLA) microfibers promote long-distance axonal regeneration in a rat model of complete spinal cord transection.
J Neural Eng, 2011 • August 1, 2011
This study investigated the possibility of using aligned, electrospun fibers loaded with a metabolic inhibitor (6AN) to selectively target astrocytes while allowing nerve growth. While it was difficul...
KEY FINDING: 6AN release from the fiber substrates occurred continuously over two weeks.
Biomaterials, 2011 • November 1, 2011
The study quantitatively compared the regenerative capacity of four polymer types (PLGA, PCLF, OPF, and OPF+) as implants within a spinal cord transection model, using Schwann cells to promote regener...
KEY FINDING: All polymers (PLGA, PCLF, OPF, and OPF+) supported axonal growth in the transected rat spinal cord model.
J Neurosurg Spine, 2011 • December 1, 2011
The authors investigated the feasibility of using injectable hydrogels, based on poly(N-isopropylacrylamide) (PNIPAAm), lightly crosslinked with polyethylene glycol (PEG) or methylcellulose (MC), to s...
KEY FINDING: The scaffolds did not worsen inflammation related to the injury.
Journal of Biomedical Optics, 2011 • October 4, 2011
This study investigates myelin integrity in mice with relapsing experimental autoimmune encephalomyelitis (EAE) using coherent anti-Stokes Raman scattering (CARS) microscopy. The research demonstrates...
KEY FINDING: Paranodal myelin retraction is an early event in relapsing experimental autoimmune encephalomyelitis (EAE), occurring at the onset of the disease and at the borders of acute demyelinating lesions.