Browse the latest research summaries in the field of urology for spinal cord injury patients and caregivers.
Showing 1-10 of 407 results
Neurourol Urodyn, 2011 • April 1, 2011
The study examined the patterns of axonal regrowth to the bladder following different nerve repair and transfer techniques in a canine model. Postmortem DiI tracing revealed that reinnervation, irresp...
KEY FINDING: Reinnervation of the bladder, regardless of the nerve source, results in innervation of both intramural ganglia and direct innervation of the detrusor muscle.
Biomech Model Mechanobiol, 2012 • January 1, 2012
This study examined the impact of mechanical strain and TGF-β1 on urinary bladder wall smooth muscle remodeling using an ex vivo organ culture system. Results showed that a 0.5-Hz strain induced elast...
KEY FINDING: A 0.5-Hz strain frequency triangular waveform stimulation at 15% strain resulted in fibrillar elastin production, collagen turnover, and a more compliant ECM.
Brain Res, 2011 • October 18, 2011
This study investigates the effectiveness of a combination therapy involving acute administration of NBQX (an AMPA/kainate receptor antagonist) and delayed transplantation of neuronal precursors (NRP/...
KEY FINDING: The combined treatment (NBQX & NRP/GRP) accelerated the recovery of bladder contraction after spinal cord injury compared to controls.
Journal of Visualized Experiments, 2012 • August 9, 2012
The study focuses on evaluating biomaterials for bladder augmentation using cystometric analyses in rodent models. Surgical implantation of gastrointestinal segments, the primary treatment for bladder...
KEY FINDING: Variations in structural and mechanical implant properties can influence the urodynamic features of tissue-engineered bladders.
BioMed Research International, 2013 • August 7, 2013
This review discusses the current status of stem cell therapy for bladder dysfunction, focusing on experimental studies using various stem cell types like ADSCs, BMSCs, and SkMSCs. The mechanisms of s...
KEY FINDING: MSCs augment healing through cell replacement, stimulation of cell proliferation, and angiogenesis, although data on bladder dysfunction repair is scarce compared to other tissues.
Biomaterials, 2014 • August 1, 2014
The study evaluated bi-layer silk fibroin (SF) scaffolds and small intestinal submucosa (SIS) matrices for bladder tissue regeneration in a rat model of spinal cord injury (SCI). Both SF and SIS scaff...
KEY FINDING: Both bi-layer SF and SIS scaffolds supported the formation of new smooth muscle layers with contractile protein expression and maturation of multi-layer urothelia.
JOURNAL OF NEUROTRAUMA, 2014 • November 1, 2014
This study investigates the effects of a TLR9 antagonist on bladder function and tissue sparing in mice with spinal cord injury (SCI). The results showed that the TLR9 antagonist decreased urinary ret...
KEY FINDING: The TLR9 antagonist (CpG ODN 2088) decreased urinary retention in mice with SCI.
SpringerPlus, 2014 • June 24, 2014
This study aimed to establish a standardized laparoscopic approach for pudendal nerve localization and electrode implantation in pigs. The laparoscopic technique proved feasible, reproducible, and saf...
KEY FINDING: Laparoscopic access to the pudendal nerve was successfully established in all pigs.
Neural Regeneration Research, 2014 • June 1, 2014
This study aimed to determine if long-term anode block electrical stimulation causes damage to the sacral nerve root in rabbits with complete spinal cord injury. The results indicated that the structu...
KEY FINDING: The structure of nerve cells in the anterior sacral nerve roots was unchanged in spinal cord injury rabbits after electrical stimulation, compared with normal rabbits.
Neural Regeneration Research, 2014 • October 1, 2014
The study investigates the effect of brachial plexus root avulsion (BPRA), with or without spinal cord injury (SCI), on erectile function in rats. Apomorphine was administered to observe changes in er...
KEY FINDING: Rats subjected to simple brachial plexus root avulsion or those subjected to brachial plexus root avulsion combined with spinal cord injury had significantly fewer erections than those subjected to the sham operation.