Clinical characteristics and molecular mechanisms underlying bladder cancer in individuals with spinal cord injury: a systematic review

This study reviews the clinical characteristics and molecular mechanisms of spinal cord injury patients with bladder cancer. The goal is to help clinicians better recognize and manage these patients. The review of existing research shows that bladder cancer occurs more frequently and is more deadly in spinal cord injury patients compared to the general population. Squamous cell carcinoma is the most common type of bladder cancer in these patients. Long-term catheter use and urinary tract infections contribute to bladder cancer development. Molecules like NO, MiR 1949 and Rb 1 also play a crucial role.

• 1
  The incidence and mortality rates of bladder cancer are higher in spinal cord injury (SCI) patients compared to the general population.
• 2
  Squamous cell carcinoma (SCC) is the most frequent pathological type of bladder cancer observed in SCI patients.
• 3
  Molecules such as NO, MiR 1949 and Rb 1 play a crucial role in the pathogenesis of bladder cancer in SCI patients, alongside long-term urinary tract infection and indwelling catheterization.