bioRxiv, 2023 · DOI: https://doi.org/10.1101/2023.12.10.571015 · Published: December 10, 2023
This study used transcriptomic and proteomic analyses to understand the molecular response in a rat model of spinal cord injury (SCI) and the potential therapeutic effects of inosine. The researchers found that spinal cord injury leads to alterations in pathways related to protein synthesis, neuroplasticity, wound healing, and neurotransmitter degradation. The study also discovered that inosine treatment can reduce markers of DNA damage and PARP activity, suggesting it has therapeutic potential for neurogenic dysfunction.
Inosine may offer a novel therapeutic approach for treating neurogenic bladder dysfunction by attenuating DNA damage and modulating key signaling pathways.
FDA-approved PARP inhibitors could potentially be repurposed for managing trauma-induced neurogenic dysfunction.
Systems biology approaches can be utilized to investigate complex neurogenic disorders and identify new therapeutic possibilities.