Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 1-10 of 7,812 results
Frontiers in Neurology, 2011 • January 4, 2011
This study analyzes the acute gene expression changes in adult rats after ventral root avulsion and replantation. Gene array analysis combined with cluster analysis of gene ontology search terms was u...
KEY FINDING: The study observed a significantly larger number of genes related to neurite growth and development in rats treated with ventral root replantation, suggesting a neuroregenerative capacity.
The Journal of Neuroscience, 2011 • January 19, 2011
This study investigates the therapeutic potential of multipotent adult progenitor cells (MAPCs) in treating spinal cord injury, focusing on their ability to modulate macrophage-mediated axonal dieback...
KEY FINDING: MAPCs significantly decrease MMP-9 release from macrophages, effectively preventing induction of axonal dieback in vitro.
J Neurosci Res, 2011 • March 1, 2011
The study examines the impact of enhanced neuronal MHCI expression on recovery after spinal cord injury (SCI) using transgenic mice. The results showed that transgenic mice with elevated neuronal MHCI...
KEY FINDING: NSE-Db mice displayed significantly improved locomotor function recovery in all key parameters compared with their locomotor abilities 1 week postlesion.
Science, 2011 • February 18, 2011
Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. We found that moderate microtubule stabilization decreased scar formation after spinal ...
KEY FINDING: Moderate microtubule stabilization decreased scar formation after SCI in rodents.
Tissue Eng Regen Med, 2022 • June 29, 2022
3D bioprinting is a new and powerful approach for SCI regeneration. Good mechanical properties of scaffolds can guide axon regeneration before being completely biodegraded, and be powerful enough to w...
KEY FINDING: 3D bioprinting is a promising method for producing complex microstructures to treat SCI.
Exp Neurol, 2012 • May 1, 2012
Regeneration and structural plasticity are regulated by a delicate balance of growth-promoting and growth-inhibiting influences in the injured adult mammalian central nervous system (CNS). Gene therap...
KEY FINDING: Injured axons remain responsive to neurotrophic factor delivery, even in chronic stages of injury, responding with enhanced neuronal survival and axon growth.
Frontiers in Neuroscience, 2011 • January 25, 2011
The study investigated the effects of pelvic and hypogastric nerve transection on sacral preganglionic neurons in adult rats, focusing on changes in gene expression and neuronal structure. Results sho...
KEY FINDING: Pelvic nerve injury led to a significant increase in c-Jun expression in sacral spinal cord neurons, particularly one week after injury.
PLoS ONE, 2011 • January 24, 2011
This study investigates whether local delivery of constitutively active Rho GTPases (CA-Cdc42 and CA-Rac1) and Brain-derived neurotrophic factor (BDNF) can alleviate CSPG-mediated inhibition of regene...
KEY FINDING: Treatment with BDNF, CA-Cdc42, or CA-Rac1 reduced the number of GFAP-positive astrocytes, as well as CSPG deposition, at the interface of the implanted hydrogel and host tissue.
Neurochem Res, 2011 • May 1, 2011
This study investigates the role of proinflammatory molecules IL-1β, TNF-α, MCP-1, MMP-9 and TIMP-1 in chronic neuropathic pain in a rodent model of SCI. The results of the study suggest that prolonge...
KEY FINDING: SCI rats showed significant impairment in locomotor function at 7 days post-injury, followed by improvement starting at day 14.
JOURNAL OF NEUROTRAUMA, 2011 • April 1, 2011
This study developed a recombinant adenovirus (Adv-GFP) that preferentially and bidirectionally labels the rubrospinal tract (RST) in rodents. Adv-GFP was used to visualize and quantify RST axons afte...
KEY FINDING: Adv-GFP preferentially and exclusively labeled the RST both retrogradely and anterogradely.