Novel phenotype characterization utilizing electrical impedance myography signatures in murine spinal cord injury neurogenic bladder models

Neurogenic bladder (NB) affects people of all ages. Electric impedance myography (EIM) assesses localized muscle abnormalities. Here, we sought to investigate whether unique detrusor EIM signatures are present in NB due to spinal cord injury (SCI). Electric impedance myography (EIM), essentially a form of localized bioimpedance measurement, is a technique that has been developed for the evaluation of neuromuscular disorders. In this study, we sought to investigate the feasibility of using EIM to detect distinct changes in the detrusor muscle in a murine SCI model.

• 1
  SCI mice had greater bladder-to-body weight ratio (p < 0.0001), greater collagen deposition (p = 0.009), and greater smooth-muscle-myosin-heavy-chain isoform A/B ratio (p < 0.0001).
• 2
  Compared with the control group, the SCI group was associated with lower phase, reactance, and resistance values (p < 0.01).
• 3
  Our study demonstrated distinct EIM alterations in the detrusor muscle of mice with NB due to SCI.