Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 1-10 of 217 results
Frontiers in Endocrinology, 2012 • February 7, 2012
This study establishes that DHEA is biosynthesized in the developing ventral neural tube at the time of neurogenesis and cell fate determination. In in vitro models, DHEA modulated the induction of ex...
KEY FINDING: DHEA induces the expression of class II protein Nkx6.1, motor neuron precursor Olig-2, and definitive motor neuron marker Isl-1/2 in vitro.
Neuroscience, 2013 • June 3, 2013
This review examines the influence of androgens on BDNF signaling within neuromuscular systems and suggests a mechanism for the trophic effects of androgens on spinal motoneurons through the androgeni...
KEY FINDING: Androgens regulate BDNF and trkB expression (the receptor for BDNF) in spinal motoneurons, influencing their morphology.
Neural Regeneration Research, 2014 • December 1, 2014
Melatonin has been shown to diminish edema in rats. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i...
KEY FINDING: Melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord after spinal cord injury.
European Journal of Sport Science, 2024 • November 1, 2024
This study assessed glycemic control in elite Para cyclists using continuous glucose monitoring (CGM). The athletes spent most of their time in euglycemia, with mild hyperglycemia after meals and duri...
KEY FINDING: Para cyclists generally maintain blood glucose levels within the normal range (euglycemia) most of the time.
EMBO Mol Med, 2022 • September 5, 2022
This study introduces a new MALDI-MSI workflow for in situ imaging of glycogen, providing spatial quantification of glycogen levels and architecture in tissues. The method reveals heterogeneous glycog...
KEY FINDING: Glycogen distribution is heterogeneous among different tissues and within different regions of the same tissue in both mice and humans.
PHARMACEUTICAL BIOLOGY, 2022 • November 21, 2022
This study investigates the therapeutic potential of veratramine for diabetic peripheral neuropathy (DPN) using a rat model. The results showed that veratramine effectively alleviates pain symptoms as...
KEY FINDING: Veratramine significantly increased the mechanical withdrawal threshold in DPN rats, indicating reduced pain sensitivity.
Frontiers in Neuroscience, 2022 • November 9, 2022
Complications after SCI significantly impact quality of life, especially gastrointestinal and bladder dysfunction. The intestinal microbiota is closely related to gastrointestinal dysfunction. After S...
KEY FINDING: SCI leads to gut dysbiosis, impacting SCFA production and associated with inflammation and infection. Gut microbiota modulates functional recovery after SCI through SCFA and the immune system. FMT may improve gastrointestinal dysfunction after SCI.
Bioscience Reports, 2022 • December 23, 2022
The study investigates the body-weight and glycemic effects of consuming a normal chow diet or a diet high in saturated fat for 16 weeks following a T10 contusion injury. The data collected show a pot...
KEY FINDING: HFD consumption equally induced weight gain in SCI and naïve rats over chow rats.
Frontiers in Endocrinology, 2023 • January 31, 2023
This study concludes that melatonin therapy was associated with improved testicular histopathological characteristics, reproductive hormonal panel, and tissue markers of oxidative stress in male roden...
KEY FINDING: Melatonin therapy was associated with improved testicular histopathological characteristics, reproductive hormonal panel, and tissue markers of oxidative stress in male rodents with physical, ischemic, and thermal testicular injuries.
J Neurol Surg B Skull Base, 2023 • July 5, 2022
This retrospective study analyzed complications in 310 patients undergoing endoscopic endonasal approach (EEA) for pituitary adenoma surgery between 2013 and 2018, identifying both minor and major com...
KEY FINDING: The overall complication rate was 18.7% in patients and 17.7% in procedures, with minor complications at 13.9% and 13.2% respectively, and major complications at 9% and 8.6% respectively.