Browse the latest research summaries in the field of urology for spinal cord injury patients and caregivers.
Showing 401-407 of 407 results
Neurourology and Urodynamics, 2020 • January 1, 2020
This study aimed to determine the effects of early sacral neuromodulation (SNM) and pudendal neuromodulation (PNM) on lower urinary tract (LUT) function in minipigs with complete spinal cord injury (c...
KEY FINDING: Early SNM improved bladder function with better capacities and lower detrusor pressures at voiding and avoided the emergence of detrusor sphincter dyssynergia (DSD).
J Neurotrauma, 2006 • July 1, 2006
The study aimed to assess the feasibility of bladder reinnervation in a canine model by transecting and immediately repairing ventral roots. Results showed that five of eight nerve transected and repa...
KEY FINDING: Transected ventral and dorsal roots in the sacral spine can be repaired and are capable of functionally reinnervating the urinary bladder.
The Journal of Neuroscience, 2006 • August 23, 2006
The study developed a rat model of cauda equina injury and repair to examine if implantation of avulsed lumbosacral ventral roots into the spinal cord could restore lower urinary tract function. The f...
KEY FINDING: Avulsion injuries led to urinary retention, absence of bladder contractions and EUS EMG activation, increased bladder size, and retrograde death of autonomic and motoneurons.
Exp Neurol, 2008 • August 1, 2008
This study investigates the urodynamic mechanisms underlying the incomplete recovery of voiding efficiency (VE) following implantation of avulsed lumbosacral ventral roots into the rat conus medullari...
KEY FINDING: The implanted series showed reflex bladder contractions with a significantly shortened urine expulsion phase compared to sham-operated controls.
Exp Neurol, 2008 • November 1, 2008
The study investigates the effects of lumbosacral ventral root avulsion (VRA) injury and re-implantation on the morphology of the rat bladder at twelve weeks post-operatively. VRA injury caused a thin...
KEY FINDING: VRA injury leads to overall thinning of the bladder wall, reduced thickness of the lamina propria and smooth muscle, and increased thickness of the bladder epithelium.
J. Cell. Mol. Med., 2011 • February 1, 2011
The study investigates the de-differentiation potential of murine glomerular epithelial cells in vitro, focusing on the role of EMT in imparting plasticity to GPECs. Results demonstrate that GPECs of ...
KEY FINDING: GPECs from adult murine kidneys can undergo EMT in vitro, leading to the generation of cells expressing CD24, CD44, and CD29 surface antigens.
PNAS, 2010 • October 26, 2010
The study investigates the role of cilia in injury and regeneration responses, focusing on the function of foxj1a, a transcriptional regulator of ciliagenes, in response to tissue damage and renal cys...
KEY FINDING: Zebrafish foxj1a, but not foxj1b, was rapidly induced in response to epithelial distension and stretch, kidney cyst formation, acute kidney injury, and crush injury in spinal cord cells.