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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Latest Research Summaries

Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.

Showing 1-10 of 12,052 results

Assistive TechnologyNeurologyBiomedical

MyoGestic: EMG interfacing framework for decoding multiple spared motor dimensions in individuals with neural lesions

Science Advances, 2025 • April 9, 2025

The study introduces MyoGestic, a neural interface system that includes a 32-channel monopolar EMG bracelet and an open-source software framework designed for rapid experimentation and adaptation to p...

KEY FINDING: The study successfully decoded motor intent in real time from participants with SCI, spinal stroke, and amputations, achieving multiple controllable motor dimensions within minutes.

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Regenerative MedicineNeurologyBiomedical

Human Schwann Cell-Derived Extracellular Vesicle Isolation, Bioactivity Assessment, and Omics Characterization

International Journal of Nanomedicine, 2025 • April 4, 2025

The study establishes a robust framework for SCEV isolation and their comprehensive characterization, which is consistent with their therapeutic potential in neurological applications. This work provi...

KEY FINDING: The study established a reliable method for isolating SCEVs with consistent molecular profiles.

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Spinal Cord InjuryGeneticsBiomedical

An engineering-reinforced extracellular vesicle–integrated hydrogel with an ROS-responsive release pattern mitigates spinal cord injury

Sci. Adv., 2025 • April 2, 2025

This study engineered mesenchymal stem cell-derived extracellular vesicles (EVs) to enhance their therapeutic efficacy for spinal cord injury (SCI) treatment. The EVs were reinforced with pro-angiogen...

KEY FINDING: The study successfully created a hydrogel that releases EVs in response to ROS, allowing for on-demand regulation of SCI treatment.

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Spinal Cord InjuryResearch Methodology & DesignPublic Health

Experienced inclusion and recognition amongst people with spinal cord injury: A comparative study in Norway, The Netherlands, and Australia

PLOS ONE, 2025 • April 1, 2025

The study investigates inclusion and recognition experienced by individuals with Spinal Cord Injury (SCI) in Norway, The Netherlands, and Australia, considering the effects of mobility limitations and...

KEY FINDING: Mobility limitations are a weaker predictor of self-perceived inclusion and recognition compared to experiences of negative attitudes towards disabled people.

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Occupational HealthNeurorehabilitationRehabilitation

Effectiveness of early vocational rehabilitation versus usual care to support RETurn to work after stroKE: A pragmatic, parallel-arm multicenter, randomized controlled trial

International Journal of Stroke, 2025 • April 1, 2025

The RETAKE trial evaluated the effectiveness of ESSVR plus usual care versus usual care alone for helping people return-to-work after stroke. The study found no evidence that ESSVR conferred any benef...

KEY FINDING: ESSVR did not show a significant benefit over usual care in improving return-to-work rates at 12 months post-stroke.

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Spinal Cord InjuryNeurologyGenetics

Pre- and post-traumatic boric acid therapy prevents oxidative stress-mediated neuronal apoptosis in spinal cord injury

Iranian Journal of Basic Medical Sciences, 2025 • April 1, 2025

The study investigates the neuroprotective efficacy of pre- and post-traumatic applications of boric acid (BA) in rats with experimentally induced spinal cord injury (SCI). The results showed that BA ...

KEY FINDING: After SCI, oxidative stress markers, such as MDA, TOS, and OSI, and apoptosis markers Cytc and Casp3 showed an increase in levels compared to Group C.

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Spinal Cord InjuryCritical CareSurgery

Time is spine: critical updates for the intensivist

Curr Opin Crit Care, 2025 • April 1, 2025

The timing of spinal decompression and hemodynamic management may impact neurological function, however, because of the deficiencies of current studies, individualized, patient-tailored decision-makin...

KEY FINDING: Early decompression (within 24 hours) may improve neurological outcomes, but the evidence is not definitive and may be influenced by study methodology and patient heterogeneity.

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NeurologyRehabilitationResearch Methodology & Design

PARAPARESIS FOLLOWING PERIPHERAL AND CENTRAL NERVOUS SYSTEM LESIONS AFTER A LIGHTNING STRIKE – A CASE REPORT

JOURNAL OF REHABILITATION MEDICINE, 2025 • April 1, 2025

This case underscores the complex nature of injuries from lightning strikes, particularly their neurological consequences, highlighting both SCI and peripheral nerve disorder. Our findings support dir...

KEY FINDING: Spinal cord imaging showed hyperintensities with a quadrifocal white matter involvement.

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Spinal Cord InjuryCardiovascular ScienceRehabilitation

Increases of peripheral blood pressure in men with cervical spinal cord injuries

Medicine, 2025 • March 28, 2025

This study investigated peripheral blood pressure (PBP) in patients with cervical spinal cord injuries (CSCI). It found that PBP was significantly higher in patients with CSCI compared to healthy cont...

KEY FINDING: Mean blood pressure (MBP) was significantly lower in patients with CSCI compared to healthy participants.

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Spinal Cord InjuryCardiovascular ScienceSurgery

Spinal cord protection by normothermic artery bypass and visceral-anastomosis-first strategy in thoracoabdominal aortic aneurysm repair

BMC Cardiovascular Disorders, 2025 • March 27, 2025

This retrospective study compared a novel surgical strategy, normothermic artery bypass and visceral-anastomosis-first (NABP), to normothermic iliac perfusion (NIP) for thoracoabdominal aortic aneurys...

KEY FINDING: The incidence of paraplegia was significantly lower in the NABP group (0.00%) compared to the NIP group (9.72%), with a p-value of 0.047.

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