Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,151-1,160 of 2,298 results
Medicina, 2023 • January 5, 2023
This study aimed to verify PRP injection safety and efficacy in LBP patients with Modic type 1. As a preliminary experiment, two LBP cases with Modic type 1 are presented. There were no adverse events ...
KEY FINDING: There were no adverse events in physical condition, laboratory data, or lumbar X-rays after injection, suggesting that PRP intradiscal injection is safe.
Journal of Nanobiotechnology, 2023 • January 9, 2023
This study investigates the facilitative effect of endothelial cell-derived exosomes (EC-EXO) on Schwann cells (SCs) and the underlying mechanisms, revealing that EC-EXO boost and maintain repair-rela...
KEY FINDING: EC-EXO can boost and maintain repair-related phenotypes of SCs, enhancing axonal regeneration, myelination, and functional recovery.
Stem Cell Research & Therapy, 2023 • January 4, 2023
This study evaluated the therapeutic potential of autogenic Low laser-activated SVF transplantation in the functional recovery and structural remodeling in the ethidium bromide-induced MS in cats. SVF...
KEY FINDING: Pelvic limb locomotion significantly recovered in the SVF co-treated group (Group III).
Advanced Healthcare Materials, 2023 • January 27, 2023
This study engineered a composite fiber with immunomodulatory and nerve repair functions for SCI treatment. The fiber's structure includes GelMA hydrogel for hydrophilicity and controlled SDF-1𝛼 rele...
KEY FINDING: The composite fiber, MS@G/S, significantly improved the hydrophilicity of the material, enhancing the integrin receptor expression on macrophage surfaces.
Int. J. Mol. Sci., 2023 • January 12, 2023
This study investigates the potential of using chondrocytes isolated from loose bodies (LB-CH) as a cell source for autologous chondrocyte implantation (ACI) to reduce donor site morbidity. LB-CH were...
KEY FINDING: LB-CH exhibited comparable viability and proliferation rates to control cells during long-term expansion, with no ultimate cell cycle arrest observed within 12 passages.
World Journal of Clinical Cases, 2023 • January 16, 2023
This review explores the potential of olfactory mucosa cells in bioprinting for treating spinal cord injuries, emphasizing their role in cell therapy due to their safety and effectiveness in nerve tis...
KEY FINDING: Olfactory mucosa cells, including NSPCs, OECs, and MSCs, show promise in cell therapy for spinal cord injuries due to their regenerative properties.
Stem Cell Research & Therapy, 2023 • January 1, 2023
This study investigates the self-renewal and differentiation potential of hypoimmunogenic human pluripotent stem cells (hPSCs) with modified HLA class I presentation. The results demonstrate that engi...
KEY FINDING: Hypoimmunogenic hPSCs, regardless of HLA molecule expression patterns, maintain normal self-renewal capacity.
Chinese Journal of Reparative and Reconstructive Surgery, 2023 • January 1, 2023
This study developed a diclofenac sodium-loaded gelatin scaffold with anti-inflammatory activity to promote cartilage regeneration in vivo. The scaffold exhibited suitable pore size, porosity, and cyt...
KEY FINDING: The diclofenac sodium-loaded gelatin scaffold significantly reduced the expression of IL-1β and TNF-α, indicating its anti-inflammatory properties.
Frontiers in Pharmacology, 2023 • January 16, 2023
This research investigates the neuroregenerative potential of Fraction B (FB) derived from catfish epidermal secretions in a rat model of sciatic nerve crush injury. The study demonstrates that FB trea...
KEY FINDING: FB treatment improved motor and sensory functions after sciatic nerve crush injury, as evidenced by improved performance in tests like foot positioning, toe spread, and thermal hyperalgesia.
Mediators of Inflammation, 2023 • January 27, 2023
This study investigates the potential of low-dose Taxol to promote axonal regeneration and functional recovery after spinal cord injury (SCI). In vitro experiments demonstrated that low-dose Taxol pro...
KEY FINDING: Low-dose Taxol promoted the differentiation of neural stem cells (NSCs) into neurons in vitro.