Laser‑activated autologous adipose tissue‑derived stromal vascular fraction restores spinal cord architecture and function in multiple sclerosis cat model

Stem Cell Research & Therapy, 2023 · DOI: https://doi.org/10.1186/s13287-022-03222-2 · Published: January 4, 2023

Regenerative Medicine Neurology Veterinary Medicine

Simple Explanation

This study explores a new treatment for multiple sclerosis (MS) using stem cells from fat tissue in cats. The stem cells, called stromal vascular fraction (SVF), were activated with a laser before being given to the cats with MS. The results showed that the treated cats had improved movement, less damage in their spinal cords, and signs of nerve repair.

Study Duration

Not specified

Participants

15 adult Persian cats

Evidence Level

Not specified

Key Findings

1
Pelvic limb locomotion significantly recovered in the SVF co-treated group (Group III).
2
BBB scores of hindlimb locomotion were significantly higher in Group III (14 ± 0.44) than Group II (4 ± 0.31).
3
The lesion’s extent and intensity were reduced in the magnetic resonance imaging (MRI) of Group III.

Research Summary

This study evaluated the therapeutic potential of autogenic Low laser-activated SVF transplantation in the functional recovery and structural remodeling in the ethidium bromide-induced MS in cats. SVF is considered an easy, valuable, and promising therapeutic approach for treating spinal cord injuries, particularly MS. The therapeutic effects of SVF improve the motor function of the hindlimb, ameliorate the lesion severity, alleviate the induced histopathological alterations, enhance the remyelination capacity.

Practical Implications

Clinical Translation Potential

The fast and excellent response, besides easily application of SVF injections in acute cases, gave attention to becoming a routine application in spinal cord injuries like accidents, MS, etc.

Further Research Needed

Further studies are required to evaluate the long-term and multiple dose effects of SVF in the treatment of spinal cord injuries.

Mechanism Elucidation

Further studies are required to understand the exact mechanism of action of laser-activated SVF in promoting regeneration and functional recovery in MS.

Laser‑activated autologous adipose tissue‑derived stromal vascular fraction restores spinal cord architecture and function in multiple sclerosis cat model

Simple Explanation

Key Findings

Research Summary

Practical Implications

Clinical Translation Potential

Further Research Needed

Mechanism Elucidation

Study Limitations

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Laser‑activated autologous adipose tissue‑derived stromal vascular fraction restores spinal cord architecture and function in multiple sclerosis cat model

Simple Explanation

Key Findings

Research Summary

Practical Implications

Clinical Translation Potential

Further Research Needed

Mechanism Elucidation

Study Limitations

Your Feedback

Was this summary helpful?