Neuroregeneration of injured peripheral nerve by fraction B of catfish epidermal secretions through the reversal of the apoptotic pathway and DNA damage

This study explores how a substance from catfish skin, called Fraction B (FB), can help nerves heal after an injury. Researchers looked at the impact of FB on nerve regeneration, especially focusing on the process of programmed cell death (apoptosis). The experiment involved rats with crushed sciatic nerves, a common model for nerve injuries. The rats were treated with different doses of FB, and the scientists observed how well their nerves recovered, looking at factors like nerve regrowth and the health of spinal cord cells. The results suggest that FB can indeed aid in nerve regeneration after a crush injury. It seems to do this by reducing cell death and promoting the survival of nerve cells. This research could potentially lead to new treatments for nerve injuries in humans.

• 1
  FB treatment improved motor and sensory functions after sciatic nerve crush injury, as evidenced by improved performance in tests like foot positioning, toe spread, and thermal hyperalgesia.
• 2
  FB enhanced Schwann cell proliferation and myelin basic protein expression, indicating improved axonal regeneration and myelin sheath formation in the injured nerves.
• 3
  FB treatment reduced neuronal cell death by inhibiting cytochrome c release and caspase-3 activation, key components of the mitochondrial-dependent apoptotic pathway.