Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,141-1,150 of 2,298 results
Frontiers in Cell and Developmental Biology, 2022 • November 24, 2022
This study developed an icariin-loaded chitosan hydrogel (ICA/CTS) for cartilage regeneration, leveraging icariin's chondrogenic and anti-inflammatory properties. In vitro results demonstrated sustain...
KEY FINDING: The ICA/CTS hydrogel exhibited a favorable in vitro anti-inflammatory effect, suppressing inflammatory-related cytokines.
Int. J. Mol. Sci., 2023 • December 28, 2022
This study investigates the ability of forced remyelination to support axon regeneration in an acute and chronic total transection model using ethidium bromide (EB) to induce focal demyelination withi...
KEY FINDING: A significant number of axons passed the injury epicenter and entered the distant segments of the spinal cord in the double-EB-injected rats. Moreover, some serotoninergic fibers, not detected in control animals, grew caudally through the injury site.
Biology, 2022 • December 19, 2022
This study compared the efficacy of local versus systemic administration of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in a rat model of spinal cord injury (SCI). The results indic...
KEY FINDING: Intravenous administration of MSC-EVs showed a higher success rate in improving motor function of hindlimbs compared to local administration.
Int. J. Mol. Sci., 2022 • December 13, 2022
This study investigates the effect of HPL on cell cycle gene expression in human stromal cells to identify key players mediating its growth-enhancing effects. The study found that HPL significantly af...
KEY FINDING: HPL significantly affected cell cycle-specific protein expression compared to FBS-based culture, with more genes being upregulated than downregulated.
Int. J. Mol. Sci., 2022 • December 14, 2022
This study explores the role of Anp32a in neuronal regeneration following spinal cord injury (SCI) in zebrafish embryos. Unlike mammals, zebrafish can quickly regenerate after SCI. The researchers used ...
KEY FINDING: Overexpression of Anp32a mRNA promotes spinal cord regeneration and resumption of swimming capability in zebrafish embryos after spinal cord injury.
Neural Regeneration Research, 2023 • July 1, 2023
This study investigates the efficacy of intravenous infusion of an autologous genetically-enriched leucoconcentrate simultaneously producing recombinant VEGF, GDNF, and NCAM on the remodeling of the s...
KEY FINDING: Higher sparing of the grey matter and increased survivability of the spinal cord cells (lower number of Caspase-3-positive cells and decreased expression of Hsp27) was observed.
Brain Res, 2015 • December 10, 2015
This study examined the properties of glial progenitors after long term culturing and following exposure to inflammatory mediators to assess their potential for SCI repair. The results demonstrated th...
KEY FINDING: Late passage GRP (grown over 120 days) maintained growth-promoting effects on neurite outgrowth from adult rat DRG, comparable to early passage GRP, in both co-culture and conditioned medium experiments.
Materials Today Bio, 2023 • December 21, 2022
Extracellular vesicles (EVs), especially those from mesenchymal stem cells (MSCs), show promise in tissue repair but are rapidly cleared by the body. Hydrogels can serve as carriers for EVs, prolongin...
KEY FINDING: EV-loaded hydrogels have shown potential in tissue repair and regeneration for skin, bone, cartilage, heart, central nervous system and reproductive organs.
Neurospine, 2022 • December 1, 2022
Traumatic spinal cord injury (SCI) disrupts the spinal cord vasculature resulting in ischemia, amplification of the secondary injury cascade and exacerbation of neural tissue loss. Restoring functiona...
KEY FINDING: Five main therapeutic approaches to diminish hypoxia-ischemia and promote vascular repair were identified as (1) the application of angiogenic factors, (2) genetic engineering, (3) physical stimulation, (4) cell transplantation, and (5) biomaterials carrying various factor delivery.
Frontiers in Cell and Developmental Biology, 2022 • December 8, 2022
This study demonstrates that Evi5 plays a crucial role in appendage regeneration in amphibians, specifically in Xenopus tadpoles. Evi5 is upregulated during limb and tail regeneration. Knockdown of Ev...
KEY FINDING: Evi5 is upregulated during limb and tail regeneration in Xenopus tadpoles, similar to its role in axolotls.