Journal of Nanobiotechnology, 2023 · DOI: https://doi.org/10.1186/s12951-023-01767-9 · Published: January 9, 2023
This study explores how endothelial cell-derived exosomes (EC-EXO) can help repair damaged nerves. Schwann cells (SCs) are crucial for nerve regeneration, and ECs contribute to creating a supportive environment. The research shows that EC-EXO can enhance the repair-related functions of SCs, leading to better nerve regeneration and recovery of nerve function after injury. The exosomes influence the expression of miR199-5p and activate a specific signaling pathway (PI3K/AKT/PTEN) within the SCs. The findings suggest that EC-EXO could be a potential therapeutic target for treating peripheral nerve injuries by promoting the natural repair mechanisms of Schwann cells.
EC-EXO can be developed as a therapeutic target for neural damage, especially in peripheral nerve injury.
EC-EXO promotes functional recovery after peripheral nerve injury by enhancing axonal regeneration, remyelination and angiogenesis.
EC-EXO can be used as therapeutic vehicles to deliver molecules directly to neurons to improve nerve regeneration following injuries, potentially leading to clinical use.