Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,161-1,170 of 2,298 results
J Lasers Med Sci, 2022 • June 23, 2022
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and accumulation of α-synuclein. Cell therapy, especially with MSCs, offers neuro...
KEY FINDING: Cell therapy, particularly using mesenchymal stem cells (MSCs), shows promise due to their self-renewal, differentiation, and immunomodulatory properties.
Cell Proliferation, 2023 • August 1, 2023
This study investigates the therapeutic potential of Wnt4-modified neural stem cells (NSCs) in treating spinal cord injury (SCI) by modulating the inflammatory microenvironment. The research demonstra...
KEY FINDING: Wnt4-modified NSCs induce M2 polarization and inhibit M1 polarization of macrophages by suppressing the TLR4/NF-κB signaling pathway in a co-culture system.
Frontiers in Molecular Neuroscience, 2023 • January 23, 2023
This editorial provides an overview of research on spinal cord development and neural regeneration, highlighting the challenges and recent developments in the field. The research topic focuses on the ...
KEY FINDING: Targeting B-RAF and PTEN simultaneously efficiently promoted DC axon growth in both the pre- and post-lesion states.
NEURAL REGENERATION RESEARCH, 2023 • December 21, 2022
The study investigates the expression of GAP-43 in the spinal cord after peripheral nerve repair using a conduit-based approach in rats. Results show that peripheral nerve regeneration induces differe...
KEY FINDING: Active regeneration of nerve gaps through the conduit was confirmed from 10 days onwards, with varied GAP-43 expression throughout the regeneration tissue.
Sci. Adv., 2023 • February 8, 2023
The study introduces a strategy using click chemistry to enhance donor cell retention and survival on scaffolds, promoting neural regeneration post-SCI. The research combines DBCO-modified scaffolds w...
KEY FINDING: Covalent conjugation (CC) between dibenzocyclooctyne-modified collagen fibers (DBCO-LACF) and azide-modified neural progenitor cells (NPCs) enhanced cell adhesion, retention, and induced cells to spread along the direction of fibers.
Communications Biology, 2023 • February 23, 2023
This study presents a refined method for generating human iPSC-derived retinal sheets, incorporating a quality control strategy and a novel preservation technique for tissue-transplantation therapy. T...
KEY FINDING: A qPCR-based quality control method was developed, allowing for selection of retinal tissue sheets suitable for transplantation.
Cells, 2023 • February 3, 2023
This study explored the therapeutic potential of injecting a mixture of rapidly expanding clone (REC) cells and ultra-purified alginate (UPAL) non-gelling solution into intervertebral discs (IVDs) to ...
KEY FINDING: The injection of REC and UPAL mixture suppressed the expression of TNF-α, IL-6, and TrkA in rat models.
Int. J. Mol. Sci., 2023 • January 28, 2023
This review summarizes recent preclinical and clinical studies using biomaterial scaffolds in regenerative therapy for SCI. It also summarizes biomaterial strategies for treatment with simplified resu...
KEY FINDING: Hydrogels, biodegradable scaffolds, micro/nano-fibers, and drug-delivering biomaterials are key categories of biomaterial scaffolds used in spinal cord regeneration. These provide structure, physical support, and biological properties for tissue constructs.
Cell Transplantation, 2023 • January 16, 2023
This study explored the role and molecular mechanism of human menstrual blood–derived endometrial stem cells (MenSCs) in spinal cord injury (SCI) using a mouse model. The results showed that MenSC tra...
KEY FINDING: MenSCs significantly improved locomotor function in SCI mice.
Bioactive Materials, 2023 • January 29, 2023
This study presents a strategy for SCI repair using 3D bioprinting to fabricate living microtissues comprised of NSCs and ECM-like hydrogel, arranged spatially to mimic native nerve fibers. The implan...
KEY FINDING: Living nerve-like fibers modulate the immune microenvironment after SCI by decreasing the number of active macrophages and increasing the ratio of M2 macrophages.