Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 1-10 of 682 results
Neurochem Res, 2011 • May 1, 2011
This study investigates the role of proinflammatory molecules IL-1β, TNF-α, MCP-1, MMP-9 and TIMP-1 in chronic neuropathic pain in a rodent model of SCI. The results of the study suggest that prolonge...
KEY FINDING: SCI rats showed significant impairment in locomotor function at 7 days post-injury, followed by improvement starting at day 14.
Gene, 2011 • July 1, 2011
The study demonstrates that miR-146a regulates cartilage-degrading proteases and pain-associated inflammatory molecules in knee joint tissues. MiR-146a functions in an anti-catabolic manner by antagon...
KEY FINDING: MiR-146a suppresses extracellular matrix proteins in human knee chondrocytes and regulates inflammatory cytokines in human knee joint synovial cells.
JOURNAL OF NEUROTRAUMA, 2012 • March 20, 2012
This study investigates the use of the Randall-Selitto test to detect and quantify neuropathic pain after spinal cord injury (SCI) in rats. The results demonstrate that the Randall-Selitto test is eff...
KEY FINDING: The Randall-Selitto test effectively detected neuropathic pain in both forepaws and hindpaws of rats with spinal cord injuries, regardless of whether the injury was a contusion or a complete transection.
Journal of Translational Medicine, 2012 • March 6, 2012
Spinal cord injury (SCI) leads to significant disability, reduced quality of life, and economic burden due to loss of productivity and lifelong supportive care. Neuropathic pain affects a significant ...
KEY FINDING: Cell-based therapies are emerging as promising therapeutic options for spinal cord regeneration and neuropathic pain mitigation after spinal cord injury.
Molecular Pain, 2012 • November 7, 2012
This study comprehensively maps the expression of Nav1.7, a key sodium channel, within the pain pathways of rat DRG neurons from peripheral skin terminals to central spinal cord terminals. The finding...
KEY FINDING: Nav1.7 is robustly expressed in small diameter DRG neurons, particularly in both peptidergic and non-peptidergic subpopulations.
Pain, 2014 • March 1, 2014
This study investigates the effect of systemic artemin administration on nerve regeneration and functional recovery in rats following different types of nerve injuries. The results showed that artemin...
KEY FINDING: Artemin transiently reversed tactile and thermal hypersensitivity following axotomy, ligation or crush injury.
Cureus, 2023 • July 29, 2023
This systematic review investigates various pharmaceutical and non-pharmaceutical interventions for managing pain in patients after spinal cord injury. The review included 57 studies, evaluating oral ...
KEY FINDING: Gabapentin and pregabalin are effective for managing chronic neuropathic pain post-SCI, with pregabalin also potentially reducing anxiety and sleep disturbances. Lamotrigine, valproate, and carbamazepine were found ineffective.
Neuroscience, 2014 • July 11, 2014
The study investigates the functional distinctions between NGF-mediated plasticity and regeneration of nociceptive axons within the spinal cord using a dorsal root entry zone model in rats. NGF-induce...
KEY FINDING: NGF-induced sprouting of CGRP axons in normal animals resulted in a significant redistribution of synapses and cFos expression into the deeper dorsal horn, leading to severe chronic pain.
Cureus, 2024 • December 24, 2024
Complex regional pain syndrome (CRPS) is a chronic pain condition characterized by significant sensory, motor, and autonomic dysfunction, often following trauma or nerve injury. The management of CRPS...
KEY FINDING: CRPS involves a complex interplay of peripheral and central mechanisms, neurogenic and classic inflammation, and potential autoimmune and psychological influences.
Neural Regen Res, 2013 • December 1, 2013
Approximately 50–70% of patients experience incision-induced mechanical nociception after surgery. However, the mechanism underlying incision-induced mechanical nociception is still unclear. Von Frey ...
KEY FINDING: Incision surgery decreased the withdrawal threshold of rats at 0.5, 3, 6 and 24 hours after incision, compared with the sham surgery group.