Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,291-2,298 of 2,298 results
BMC Neuroscience, 2010 • November 23, 2010
This study examines the intrinsic response of long descending propriospinal tract (LDPT) neurons to axotomy following a low thoracic spinal cord injury (SCI) in rats, comparing their response to short...
KEY FINDING: LDPT neurons exhibit a broad down-regulation of genes related to growth factors and axonal regeneration early after a low thoracic spinal cord injury.
CELLULAR REPROGRAMMING, 2010 • December 1, 2010
The study introduces a novel animal model for SCI research using cloned Yucatan minipigs, focusing on sacrocaudal spinal cord transection to induce tail paralysis while preserving other motor function...
KEY FINDING: Transection of the sacrocaudal spinal cord in Yucatan minipigs induces quantifiable tail paralysis without causing impairment in pelvic limb, urinary, or bowel functions.
The Journal of Neuroscience, 2010 • December 1, 2010
The study assessed the impact of soleus (SOL) H-reflex up-conditioning on the recovery of SOL and tibialis anterior (TA) EMG activity and reflexes following sciatic nerve transection and repair in rat...
KEY FINDING: SOL (and probably TA) background EMG activity recovered faster in TU rats than in TC rats.
PLoS ONE, 2010 • December 20, 2010
This study aimed to assess the synergistic protective effect of human mesenchymal stem cells (hMSCs) and pituitary adenylate cyclase-activating polypeptide (PACAP) on functional recovery in rats with ...
KEY FINDING: Delayed treatment with PACAP and hMSCs at day 7 post SCI increased the remaining neuronal fibers in the injured spinal cord, leading to better locomotor functional recovery in SCI rats when compared to treatment only with PACAP or hMSCs.
Neural Development, 2011 • January 4, 2011
This study details the cellular and extracellular events during newt spinal cord regeneration after transection injury. It emphasizes the crucial role of meningeal and glial cells in promoting axon re...
KEY FINDING: Axon regeneration following spinal cord transection involves six stages: retraction, growth initiation, wrapping, wisping, spiking, and contact and growth beyond the injury site.
PLoS ONE, 2010 • December 30, 2010
The study investigated the effects of transplanting human embryonic neural progenitors (hENPs), with or without Neurogenin-2 (Ngn2) expression, into rats with severe spinal cord injuries. Results show...
KEY FINDING: Transplantation of hENPs expressing Ngn2 improved motor recovery after severe spinal cord compression in rats.
JOURNAL OF NEUROTRAUMA, 2011 • April 1, 2011
This study investigated the effects of transplanting human glial-restricted progenitors (hGRP) and astrocytes derived from hGRP (hGDA) into a rat model of spinal cord contusion injury. The results sho...
KEY FINDING: Both hGRP and hGDA grafts demonstrated robust survival and extensive migration within the injured spinal cord, with a threefold increase in cell number for hGRP and a twofold increase for hGDA.
PLoS ONE, 2011 • April 22, 2011
This study uses lipidomic and peptidomic assays coupled to molecular mass spectrometry imaging to explore molecular changes after injury in the leech CNS. The study identifies proteins involved in cyt...
KEY FINDING: Increased levels of proteins thought to play important roles in early stages of neural development were observed in the regenerating adult leech CNS.