Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 101-110 of 730 results
Int. J. Mol. Sci., 2022 • December 14, 2022
This study demonstrates that loganin, an iridoid glycoside, can modulate autophagic flux in a rat model of chronic constriction injury (CCI)-induced neuropathic pain. The results indicate that loganin...
KEY FINDING: Loganin attenuated the expression of Beclin-1, LC3B-II, and p62 in CCI rats, suggesting an improvement in autophagic flux.
Brain and Behavior, 2023 • January 1, 2023
Neuropathic pain (NP) involves abnormal sensory signals across the nervous system, leading to significant pain. Neuron-glial cell interaction is related to the pathogenesis of NP, with activation of m...
KEY FINDING: The microglia P2X4 receptor plays a central role in neuropathic pain, activating pathways that affect both astrocytes and neurons.
Frontiers in Immunology, 2022 • December 22, 2022
The study investigates the role of the XCL1 chemokine and its receptors, XCR1 and ITGA9, in neuropathic pain using a chronic constriction injury (CCI) model in mice. Key findings include the upregulat...
KEY FINDING: XCL1 expression increases in the spinal cord after nerve injury and is mainly produced by astroglial cells.
The Journal of Spinal Cord Medicine, 2023 • July 1, 2023
The study aimed to characterize the distribution of pathogens in UTI patients with spinal cord injuries (SCI) and their resistance to antibiotics. The meta-analysis of 33 studies revealed that UTIs in...
KEY FINDING: UTIs in patients with SCI in China are mainly caused by gram-negative bacteria.
Frontiers in Immunology, 2023 • January 6, 2023
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with significant loss of function and/or permanent disability. The pathophysiology of SCI is complex and occurs in...
KEY FINDING: Following tSCI, the immune response likely exerts both beneficial and harmful roles and as previously discussed both the innate and adaptive immune systems have been implicated in secondary injury progression in tSCI.
J Clin Invest, 2023 • March 1, 2023
Microglia, resident macrophages of the CNS, are essential to brain development, homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS diseases, including neuropat...
KEY FINDING: TRPV4 is functionally expressed in spinal resident microglia and its expression is increased in a mouse model of spared nerve injury (SNI).
Frontiers in Oncology, 2023 • January 10, 2023
The study reports three cases of IgG4-RSP and reviews 45 cases total, highlighting the disease's clinical presentations, radiological manifestations, treatment, and prognosis. Key findings include the...
KEY FINDING: Progressive worsening of neurological impairment was observed in nearly half of the patients (48.9%).
Antimicrobial Stewardship & Healthcare Epidemiology, 2022 • November 5, 2022
This study evaluated the appropriateness of ASB and UTI management in hospitalized patients with NB, finding a high proportion of inappropriate UTI diagnoses and treatments. The study highlights the n...
KEY FINDING: Almost one-third of UTI diagnoses and half of treatments in hospitalized patients with NB are inappropriate.
Molecular Pain, 2023 • January 25, 2023
This study investigated the effects of Resolvin D1 (RvD1) on mechanical allodynia after burn injury in rats. The researchers found that RvD1 attenuated mechanical allodynia, prevented glial activation...
KEY FINDING: RvD1 attenuates mechanical allodynia after burn injury in rats.
Journal of Neuroinflammation, 2023 • February 3, 2023
This study investigates the potential of inducible co-stimulatory molecule (ICOS) in resolving CIPN pain-like behaviors in mice, finding that ICOS agonist antibody (ICOSaa) alleviates mechanical hyper...
KEY FINDING: ICOS agonist antibody (ICOSaa) promotes paclitaxel-evoked pain resolution in female mice.