Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 1-10 of 730 results
J Neurosci Res, 2011 • March 1, 2011
The study examines the impact of enhanced neuronal MHCI expression on recovery after spinal cord injury (SCI) using transgenic mice. The results showed that transgenic mice with elevated neuronal MHCI...
KEY FINDING: NSE-Db mice displayed significantly improved locomotor function recovery in all key parameters compared with their locomotor abilities 1 week postlesion.
The Journal of Neuroscience, 2011 • March 16, 2011
This study investigates the cellular and molecular changes following peripheral nerve grafts and aFGF treatment that improve hindlimb locomotor function in spinal cord-transected rats. The repair stra...
KEY FINDING: The study found that a combination of peripheral nerve grafts and acidic fibroblast growth factor (aFGF) induced higher levels of interleukin-4 (IL-4), IL-10, and IL-13 in the graft areas of rat spinal cords.
CNS Drugs, 2011 • July 1, 2011
Repair of the central nervous system (CNS) constitutes the integral part in treating neurologic diseases and plays a crucial role in restoring CNS architecture and function. In this review, we discuss...
KEY FINDING: The major challenges of CNS repair include neurodegeneration and pathological obstacles impeding neural cell growth after CNS injury.
Journal of Neuroinflammation, 2011 • July 6, 2011
This study investigates whether GSNO promotes neurorepair processes by reducing peroxynitrite levels and oxidative injury in rats after TBI. The results demonstrate that GSNO reduces peroxynitrite, pr...
KEY FINDING: GSNO treatment reduced peroxynitrite, lipid peroxides/aldehydes, BBB leakage, inflammation, and edema in the short term (4-48 hours) following TBI in rats.
Brain Pathology, 2012 • January 1, 2012
The study characterized the composition and distribution of spinal cord ECM during TMEV infection to identify underlying molecular mechanisms and transcriptional changes. Microarray analysis revealed ...
KEY FINDING: Progressive accumulation of chondroitin sulfate proteoglycans, glycoproteins, and collagens occurred within demyelinated TME lesions, paralleling astrogliosis development.
Glia, 2011 • December 1, 2011
This study investigates the role of CXCR4 signaling in regulating remyelination by endogenous oligodendrocyte progenitor cells (OPCs) in a viral model of demyelination. The findings suggest that CXCR4...
KEY FINDING: CXCR4 signaling is required for OPCs to mature and contribute to remyelination in response to JHMV-induced demyelination.
Journal of Neuroinflammation, 2011 • August 30, 2011
Successful peripheral axon regeneration is associated with a rapid and efficient inflammatory response that is terminated in due course. Schwann cells and macrophages communicate via cytokine networks...
KEY FINDING: Axon degeneration in the distal nerve instigates subsequent degenerative processes after PNI; however, axon degeneration does not begin immediately.
Brain, 2011 • September 1, 2011
This study investigates the distinct roles of soluble TNF and transmembrane TNF in experimental autoimmune encephalomyelitis (EAE) using pharmacological inhibitors. The researchers found that selectiv...
KEY FINDING: Selective inhibition of soluble TNF with XPro1595 improves the clinical outcome in experimental autoimmune encephalomyelitis (EAE).
Journal of Biomedical Optics, 2011 • October 4, 2011
This study investigates myelin integrity in mice with relapsing experimental autoimmune encephalomyelitis (EAE) using coherent anti-Stokes Raman scattering (CARS) microscopy. The research demonstrates...
KEY FINDING: Paranodal myelin retraction is an early event in relapsing experimental autoimmune encephalomyelitis (EAE), occurring at the onset of the disease and at the borders of acute demyelinating lesions.
Journal of Neuroinflammation, 2011 • November 13, 2011
This study examines the role of NG2, a proteoglycan expressed by OPCs, pericytes, and macrophages/microglia, in spinal cord demyelination and remyelination using wild type and NG2 null mice. Results s...
KEY FINDING: The initial volume of spinal cord demyelination in wild type mice is twice as large as in NG2 null mice, suggesting NG2 influences the initial damage phase.