The Iridoid Glycoside Loganin Modulates Autophagic Flux Following Chronic Constriction Injury-Induced Neuropathic Pain

This study investigates the effects of loganin, a natural compound, on neuropathic pain caused by nerve damage in rats. Neuropathic pain is a chronic condition that is difficult to treat. The researchers found that loganin can improve neuropathic pain by stimulating a cellular process called autophagy, which helps to clear damaged components from cells. Loganin also reduced inflammation and cell death in the spinal cord of the rats. These findings suggest that loganin could be a potential treatment for neuropathic pain by promoting autophagy and reducing inflammation in the nervous system.

• 1
  Loganin attenuated the expression of Beclin-1, LC3B-II, and p62 in CCI rats, suggesting an improvement in autophagic flux.
• 2
  Loganin reduced the accumulation of LC3B-II and p62 in spinal microglia and astrocytes, indicating improved autophagy in these cells.
• 3
  Loganin lessened the CCI-increased apoptosis protein Bax and cleaved caspase-3, demonstrating a reduction in cell death.