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  4. Clinical outcomes associated with guideline-discordant management of asymptomatic bacteriuria and urinary tract infection in hospitalized patients with neurogenic bladder

Clinical outcomes associated with guideline-discordant management of asymptomatic bacteriuria and urinary tract infection in hospitalized patients with neurogenic bladder

Antimicrobial Stewardship & Healthcare Epidemiology, 2022 · DOI: 10.1017/ash.2022.348 · Published: November 5, 2022

UrologyImmunologyHealthcare

Simple Explanation

The study examines the management of asymptomatic bacteriuria (ASB) and urinary tract infections (UTI) in hospitalized patients with neurogenic bladder (NB). It assesses whether the diagnosis and treatment of ASB and UTI align with national guidelines and how guideline adherence impacts patient outcomes. The goal is to identify opportunities to improve antibiotic use and patient care in this population.

Study Duration
2 Years
Participants
170 encounters with ASB or UTI diagnoses occurring for 166 patients with neurogenic bladder
Evidence Level
Retrospective cohort study

Key Findings

  • 1
    Almost one-third of UTI diagnoses and half of treatments in hospitalized patients with NB are inappropriate.
  • 2
    All ASB encounters had appropriate diagnoses, and 96.1% had appropriate treatment.
  • 3
    Appropriate ASB or UTI diagnosis was associated with a longer postculture LOS in patients with SCI/D or MS.

Research Summary

This study evaluated the appropriateness of ASB and UTI management in hospitalized patients with NB, finding a high proportion of inappropriate UTI diagnoses and treatments. The study highlights the need for antimicrobial stewardship initiatives in inpatient rehabilitation, LTCF, and SCI/D units. Associations between inappropriate ASB and UTI management and clinical outcomes reflect a complex relationship influenced by patient, institutional, and provider factors.

Practical Implications

Improve Diagnostic Stewardship

Implement diagnostic stewardship interventions, particularly targeting hospitalized patients with NB, to reduce unnecessary urine cultures and antibiotic use.

Enhance Provider Education

Educate healthcare providers, especially those in inpatient rehabilitation, LTCF, and SCI/D units, on the appropriate diagnosis and management of ASB and UTI in patients with NB.

Customize Stewardship Tools

Develop customized antimicrobial stewardship tools that consider bacterial susceptibility patterns in patients with SCI/D to optimize antibiotic choices.

Study Limitations

  • 1
    VA data may not be fully representative of all NB patients.
  • 2
    Accuracy limited by documentation in electronic health records.
  • 3
    Small sample size limits adjusted multivariable models.

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