Immunology Research

KEY FINDING: Endogenous hCAST expression protects axonal and nodal integrity in an acute ex vivo injury model, as evidenced by the attenuation of neurofilament breakdown.

KEY FINDING: Microglial activation in the motor cortex (M1) mediates NLRP3-related neuroinflammation following SCI.

KEY FINDING: AR upregulation in the spinal cord correlated with inactivated SIRT1–AMPK–mTOR pathway and disrupted autophagy following BPRA.

KEY FINDING: Differential glycosylation occurs in glial cells during the transition from acute to chronic inflammation in a mixed glial culture model induced by cytokines.

KEY FINDING: A 66-year-old patient with a history of pulmonary tuberculosis presented with cervical Pott's disease, characterized by neck pain, tingling, and heaviness in the upper limbs.

KEY FINDING: GSK189254 reversed mechanical and thermal allodynia in SNI mice, but this effect was prevented by blocking H4R with JNJ 10191584.

KEY FINDING: The review identifies multiple potential therapeutic targets, including modulation of inflammation with nanotherapeutics, heme oxygenases, and apelin-13; reduction of oxidative stress; and neuro-regeneration strategies.

KEY FINDING: Clec7a is significantly upregulated in spinal cord tissues of rats with chronic constriction injury (CCI), a model for neuropathic pain.

KEY FINDING: HMGB2 expression is elevated in the spinal cord tissues of rats following SCI, particularly at day 3 after injury.

KEY FINDING: Intramedullary spinal neurosarcoidosis can mimic spondylotic myelopathy both clinically and on imaging.