Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 721-730 of 730 results
The Journal of Clinical Investigation, 2009 • October 1, 2009
This study demonstrates that B cells, through antibody production, negatively impact recovery after spinal cord injury (SCI) in mice. Mice lacking B cells exhibit improved locomotor function and reduc...
KEY FINDING: Mice lacking B cells showed improved locomotor recovery and reduced lesion volume compared to wild-type mice after spinal cord injury.
The Journal of Clinical Investigation, 2009 • October 1, 2009
The commentary discusses a study that identifies a new immunopathological mechanism arising after spinal cord injury (SCI) in mice. The study demonstrates that B cells produce pathogenic antibodies th...
KEY FINDING: Spinal cord injury leads to a B cell response that produces pathogenic antibodies.
Retrovirology, 2024 • May 10, 2024
This study investigates the impact of two HIV-1 strains (HIV-1JR-CSF and HIV-1CH040) on CNS pathology in humanized mice, focusing on neuronal injury and neuroinflammation across various brain regions ...
KEY FINDING: HIV-infected human cells were found in the brains of HIV-infected BLT mice, confirming HIV neuroinvasion.
PNAS, 2009 • December 8, 2009
This study characterizes a system-wide infiltration of macrophages in the PNS of mutant SOD1 mice that accompanies axon degeneration in ventral roots, sciatic nerves, and muscle tissues. The origin an...
KEY FINDING: Macrophages are activated throughout the PNS in mutant SOD1G93A and SOD1G37R transgenic mouse models of ALS.
Brain, 2010 • January 19, 2010
This study characterizes a novel cell preparation method that assesses, quickly and effectively, the changes in the principal immune cell types by flow cytometry in the injured spinal cord, daily for t...
KEY FINDING: The study quantitatively demonstrates a novel time-dependent multiphasic response of cellular inflammation in the spinal cord after spinal cord injury.
J Clin Immunol, 2010 • May 1, 2010
The study identifies natural human IgM antibodies that can promote remyelination in animal models of demyelinating diseases like multiple sclerosis (MS). These antibodies bind to oligodendrocytes and ...
KEY FINDING: Two human IgMs (sHIgM22 and sHIgM46) were identified that promoted significant remyelination in TMEV-infected mice, suggesting potential therapeutic applications.
J Clin Immunol, 2010 • May 1, 2010
Spinal cord injury (SCI) involves a primary mechanical trauma followed by a secondary injury cascade, including neuroinflammation, that exacerbates the initial damage. Neuroinflammation, while importa...
KEY FINDING: IgG can modulate the immune response by inducing apoptosis in leukocytes, neutralizing components of the complement system, and inhibiting the activation of leukocytes.
Cell Mol Neurobiol, 2010 • July 14, 2010
This is a retraction note for an article originally published online on July 14, 2010, in Cellular and Molecular Neurobiology. The reason for the retraction is the duplication of a significant amount ...
KEY FINDING: The original article (DOI 10.1007/s10571-009-9449-4) has been retracted.
Journal of Inflammation, 2010 • October 25, 2010
This study investigates the in vivo immuno-regulatory effectiveness of human mesenchymal stem cells (hMSCs) using an ovalbumin challenge model of acute asthma in mice. The results demonstrate a direct...
KEY FINDING: hMSCs are well tolerated in the murine model of acute asthma, suggesting that hMSCs can favorably change the outcome of asthmatic inflammation without the pathology associated with cross-species application.
Molecular Pain, 2011 • January 5, 2011
This study investigates whether a preconditioning nerve lesion influences pain sensation and neuroinflammation following a subsequent peripheral nerve injury. The results show that a preconditioning c...
KEY FINDING: A preconditioning crush injury to the tibial nerve significantly attenuated mechanical allodynia and thermal hyperalgesia following partial sciatic nerve ligation (PSNL).