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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Latest Research Summaries

Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.

Showing 31-40 of 12,052 results

Spinal Cord InjuryNeurologyGenetics

SGK1 upregulation in GFAP+ neurons in the frontal association cortex protects against neuronal apoptosis after spinal cord injury

Cell Death and Disease, 2025 • March 17, 2025

This study investigates the mechanisms underlying cognitive deficits and emotional disorders after spinal cord injury (SCI). The researchers used a GFAP-IRES-Venus-AkaLuc knock-in mouse model to study...

KEY FINDING: Spinal cord transection (SCT) surgery led to increased bioluminescence in the brain, particularly in the frontal association cortex (FrA).

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Spinal Cord InjuryNeurologyNeurorehabilitation

nTMS in spinal cord injury: Current evidence, challenges and a future direction

Brain and Spine, 2025 • March 14, 2025

This article provides an overview of different assessment and therapeutic strategies using nTMS and reviews their effectiveness in spinal cord injury (SCI). The review explores the current state of nT...

KEY FINDING: nTMS can be used in assessment and treatment of patients with both traumatic and non-traumatic SCI. When it is being used in the assessment of SCI it can provide objective outcome measures that can add to the existing scales that are currently being used.

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Assistive TechnologyNeurologyRehabilitation

Combining functional electrical stimulation with visual feedback balance training: a qualitative study of end-­user perspectives on designing a clinically feasible intervention

BMJ Open, 2025 • March 14, 2025

This study used a participatory design approach to identify potential challenges and solutions for implementing a functional electrical stimulation with visual feedback balance training (FES+VFBT) sys...

KEY FINDING: End-users identified challenges such as lack of knowledge about the system, safety concerns, technical difficulties, cost, limited time and space, and suggested solutions at different levels.

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Spinal Cord InjuryCardiovascular ScienceGastroenterology

Multifaceted challenges of deep venous thrombosis in the setting tetraplegia and ulcerative colitis: case report

Spinal Cord Series and Cases, 2025 • March 14, 2025

This case highlights the challenges in managing DVT in post-surgical patients, specifically in patients with tetraplegia and bleeding risks. The management of patients with concurrent IBD and acute tra...

KEY FINDING: A 53-year-old male with UC and traumatic tetraplegia developed a below the knee DVT during inpatient rehabilitation, despite DVT prophylaxis.

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RheumatologyNeurologyPediatrics

Diagnosis, treatment, and functional outcomes for two adolescent female patients with lupus myelitis: a case report

Front. Rehabil. Sci., 2025 • March 14, 2025

This case series describes the presentation, diagnostic evaluation, treatment, and functional outcomes of two adolescent female patients diagnosed with lupus myelitis as a first manifestation of new-on...

KEY FINDING: Early aggressive immunomodulatory treatment (IMT) and intensive inpatient rehabilitation led to significant laboratory and functional improvement in both patients.

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Spinal Cord InjuryNursingRehabilitation

Development of the nurse care assessment for in-hospital spinal cord injury rehabilitation

Spinal Cord Series and Cases, 2025 • March 14, 2025

The study developed and evaluated the Nurse Care Assessment for in-hospital Spinal Cord Injury Rehabilitation (NCA-SCI) to categorize the care needs of inpatients with spinal cord injuries. The NCA-SC...

KEY FINDING: The NCA-SCI was developed through an iterative process involving experienced clinicians, resulting in a 17-item tool across five categories of nursing assistance.

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UrologyEndocrinologyWomen's Health

Recent Advances in the Diagnosis and Management of Retrograde Ejaculation: A Narrative Review

Diagnostics, 2025 • March 14, 2025

Retrograde ejaculation (RE) is a condition where the forward expulsion of seminal fluid is impaired, leading to infertility and psychological distress in affected individuals. Management strategies for...

KEY FINDING: Diagnosis of RE relies on patient history, lab analysis of post-ejaculatory urine samples, and advanced imaging.

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Spinal Cord InjuryBioinformatics

Establishment and validation of a ResNet-based radiomics model for predicting prognosis in cervical spinal cord injury patients

Scientific Reports, 2025 • March 13, 2025

This study developed a combined radiomics and clinical model to predict the prognosis of cSCI patients six months post-injury. The model integrates radiomic features extracted using Pyradiomics and Re...

KEY FINDING: The SVM classifier achieved the highest AUC of 1.000 in the training set and 0.915 in the testing set for radiomics models.

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PharmacologyPain ManagementBioinformatics

Using Integrated Network Pharmacology and Metabolomics to Reveal the Mechanisms of the Combined Intervention of Ligustrazine and Sinomenine in CCI-Induced Neuropathic Pain Rats

Int. J. Mol. Sci., 2025 • March 13, 2025

This study aimed to elucidate the molecular mechanisms underlying the combined use of LGZ and SIN in treating NP using network pharmacology and metabolomics. The combination of LGZ and SIN demonstrate...

KEY FINDING: The combination of LGZ and SIN significantly alleviated pain-like behaviors in CCI rats in a time- and dose-dependent manner, demonstrating superior therapeutic effects compared to LGZ or SIN alone.

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Spinal Cord InjuryMedical ImagingOrthopedics

T2‑weighted MRI high signal in cervical spondylotic myelopathy is associated with dynamic change

Journal of Orthopaedic Surgery and Research, 2025 • March 13, 2025

This study investigates the relationship between high-signal intensity on MRI-T2WI and cervical dynamic change using kinematic MRI to determine risk factors associated with high signals. The degree of...

KEY FINDING: The degree of cord compression was remarkably increased in both groups with cervical ranging from flexion to extension.

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