Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 21-30 of 12,052 results
Int. J. Mol. Sci., 2025 • March 19, 2025
This study investigated the role of central serotonin in sensorimotor recovery after spinal cord injury (SCI) using tryptophan hydroxylase 2 knockout (TPH2 KO) rats, which lack serotonin in the brain ...
KEY FINDING: TPH2 KO rats exhibited a significantly higher degree of sensorimotor deficit in the tapered beam walking test (TBW) and ladder walking test (LW) compared to WT rats in the 3rd and 4th weeks after SCI.
Journal of Neural Engineering, 2025 • March 19, 2025
This paper introduces the HD64, a novel high-density active electronic epidural paddle for spinal cord neuromodulation. The device integrates a 60-electrode programmable array with an active electroni...
KEY FINDING: The active paddle array (HD64) performed nominally when implanted in sheep for over 15 months, and no device-related malfunctions were observed.
Frontiers in Pharmacology, 2025 • March 19, 2025
The study investigates the therapeutic effects of teriparatide in a rat model of SCI, focusing on its ability to mitigate oxidative stress and improve neurological recovery. Results demonstrate that t...
KEY FINDING: Teriparatide treatment significantly enhanced motor function recovery post-SCI in rats, as assessed by open field tests and BBB scoring.
Cell Reports Medicine, 2025 • March 18, 2025
The study develops injectable GelMA hydrogels with controlled mechanical properties containing targeting miR-222-engineered extracellular vesicles (TeEVs). These injectable patches facilitate the prec...
KEY FINDING: Targeting miR-222-engineered EVs are incorporated in mechanical GEL hydrogels
Neurol. Int., 2025 • March 18, 2025
This study aimed to determine the responsiveness and minimal important change (MIC) of the Mini-BESTest and Brief-BESTest in people with subacute iCSCI. Changes in BBS scores were moderately positivel...
KEY FINDING: Changes in balance test scores (Mini-BESTest and Brief-BESTest) were moderately related to changes measured by the Berg Balance Scale (BBS).
Metabolic Brain Disease, 2025 • March 18, 2025
This study investigates the potential of sodium butyrate (NaB) to alleviate spinal cord injury (SCI) by inhibiting pyroptosis. It establishes that SCFAs levels, particularly butyric acid, are signific...
KEY FINDING: SCFAs levels, especially butyric acid, significantly decreased after SCI, indicating changes in gut flora metabolites.
Front. Public Health, 2025 • March 18, 2025
This study examined risk factors and economic impacts of long-term nursing care (LTC) after major trauma in Taiwan using National Health Insurance Research Database data from 2003-2007 with a 10-year ...
KEY FINDING: Age, comorbidities, spinal cord injury, prolonged mechanical ventilation, prolonged ICU stay, and prolonged hospital stay are independent risk factors for needing long-term nursing care (LTC).
BMC Pediatrics, 2025 • March 17, 2025
This retrospective study examined factors influencing functional independence outcomes in children with spinal cord injury (SCI) undergoing inpatient rehabilitation. The study identified that shorter ...
KEY FINDING: The total SCIM-III score significantly improved from admission to discharge (p < 0.001), indicating functional gains during rehabilitation.
Patient Preference and Adherence, 2025 • March 17, 2025
This study evaluated bladder management and follow-up adherence among individuals with spinal cord injury (SCI) and neurogenic lower urinary tract dysfunction (NLUTD). The research revealed insufficie...
KEY FINDING: CIC is the preferred method for bladder emptying, especially among individuals with thoracic and lumbar SCI.
Neurochemical Research, 2025 • March 17, 2025
The study examined the protective effect of DEX on remifentanil-induced hyperalgesia in rats. Remifentanil, while effective for pain relief, can paradoxically increase pain sensitivity. The findings i...
KEY FINDING: DEX administration reduced mechanical allodynia and thermal hyperalgesia in rats experiencing remifentanil-induced hyperalgesia (RIH).