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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Latest Research Summaries

Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.

Showing 201-210 of 12,052 results

Spinal Cord InjuryGeneticsBiomedical

Engineered Extracellular Vesicles from Antler Blastema Progenitor Cells: A Therapeutic Choice for Spinal Cord Injury

ACS Nano, 2025 • January 22, 2025

The study demonstrates that EVs derived from ABPCs (EVsABPC) are more effective in promoting neural regeneration, modulating immune response, and improving functional recovery in SCI models compared t...

KEY FINDING: EVsABPC significantly enhanced the proliferation of neural stem cells (NSCs) and activated neuronal regenerative potential, resulting in a 5.2-fold increase in axonal length.

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Spinal Cord InjurySurgeryPediatrics

Hidden cause of paralysis: tight filum terminale in spinal cord injury without radiographic abnormality

Frontiers in Pediatrics, 2025 • January 22, 2025

This study retrospectively analyzed the clinical data of four SCIWORA patients treated at our hospital from November 2022 to June 2024, exploring their injury mechanisms, clinical features, spinal cor...

KEY FINDING: All four patients had thoracolumbar injuries with rapid progression of symptoms, including paralysis, sensory impairment, and urinary and fecal retention.

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Spinal Cord InjuryRehabilitation

GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury

PLOS ONE, 2025 • January 22, 2025

This study explored the combined effects of GsMTx-4 and exercise on rats with spinal cord injury (SCI), focusing on soleus muscle structure and motor function. The combination therapy showed significa...

KEY FINDING: The combination therapy significantly improved motor function, as measured by the Basso–Beattie–Bresnahan score and Gait Symmetry.

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RehabilitationDisabilityPublic Health

Community Integration of Disability: A Bibliometric and Knowledge-Map Analysis

Journal of Multidisciplinary Healthcare, 2025 • January 22, 2025

This review used CiteSpace, the most commonly used bibliometric analysis software worldwide, to visually analyze research on community integration of individuals with disabilities from 1990 to 2023. F...

KEY FINDING: The number of publications related to community integration is increasing gradually.

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Mental HealthPediatricsDisability

Exploring the Extent and Nature of Disordered Eating Among Canadian Adolescents and Young Adults With Spina Bifida and Hydrocephalus

Child: Care, Health and Development, 2025 • January 22, 2025

This study support previous suggestions that AYA with disabilities—and SBH specifically—likely face an elevated risk for eating disorders/disordered eating and poor body image, due to a complex combin...

KEY FINDING: AYA with SBH may face an elevated risk for eating disorders/disordered eating compared to typically developing peers due to bowel/bladder management, mobility issues, and eating aversions.

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Spinal Cord InjuryPhysiologyNeurology

Electrical stimulation of the sciatic nerve restores inspiratory diaphragm function in mice after spinal cord injury

Frontiers in Neural Circuits, 2025 • January 22, 2025

This study investigates the effects of electrical stimulation of the sciatic nerve on diaphragm activity in healthy and spinal cord injured mice. The study found that electrical stimulation can increa...

KEY FINDING: Electrical stimulation of the sciatic nerve can increase diaphragm activity in uninjured mice, confirming previous findings in other species.

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Spinal Cord InjuryCritical CareRehabilitation

Early exercise therapy in patients with severe traumatic spinal cord injury: is it feasible in the ICU?

Critical Care, 2025 • January 22, 2025

As part of the PROMPT-SCI trial, 45 adult patients were recruited from a single Level-1 trauma center in Montreal, Canada, between April 2021 and August 2023. The intervention consisted of daily 30-mi...

KEY FINDING: This study supports the safety and feasibility of passive in-bed leg cycling in ICU patients with severe TSCI.

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Spinal Cord InjuryRegenerative MedicineBiomedical

Metabolic Reprogramming of Neural Stem Cells by Chiral Nanofiber for Spinal Cord Injury

ACS Nano, 2025 • January 22, 2025

This study introduces a novel method using a chiral nanofiber-based extracellular matrix (ECM) to metabolically reprogram neural stem cells (NSCs) for spinal cord injury (SCI) treatment. The dextral n...

KEY FINDING: Dextral hydrogel (DH) promotes neural differentiation of NSCs and improves neural regeneration in rat SCI models by regulating fatty acid metabolism of NSCs.

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Cardiovascular ScienceSurgery

Impact of mild hypothermic circulatory arrest on surgical outcomes in acute type a aortic dissection patients: a single-centre study

BMC Cardiovascular Disorders, 2025 • January 21, 2025

This retrospective study of 447 ATAAD patients undergoing urgent TAR and FET found that MI-HCA was associated with shorter CPB time and reduced blood transfusion needs. MI-HCA patients had better post...

KEY FINDING: MI-HCA was associated with a shorter CPB time, and reduced blood transfusion requirements.

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PhysiologyNeurologyPain Management

Establishing an Electrophysiological Recording Platform for Epidural Spinal Cord Stimulation in Neuropathic Pain Rats

Journal of Pain Research, 2025 • January 21, 2025

The study comprehensively analyzed methodology and technical challenges and pitfalls encountered during the development and implementation of this model. We presented a reliable electrophysiological p...

KEY FINDING: SNI enhanced the C component of eLFPs in bilateral cortexes elicited by stimulating the contralateral but not the ipsilateral lateral aspect of the hind paw.

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