Browse the latest research summaries in the field of mental health for spinal cord injury patients and caregivers.
Showing 1-10 of 289 results
Neurotrauma Reports, 2023 • January 1, 2023
This article addresses the gap in clinical literature regarding the use of serotonergic psychedelics by persons with spinal cord injury (SCI). The authors describe a unique set of adverse events repor...
KEY FINDING: Persons with SCI report a consistent pattern of neuromuscular and autonomic hypersensitivity to classical serotonergic psychedelics, including intense muscle spasms, sweating, and tremors.
BioMed Research International, 2014 • May 14, 2014
This review discusses the structure and function of chondroitin sulfate proteoglycans (CSPGs) in both healthy states and in the context of genetic disorders affecting the brain. The reviewed studies h...
KEY FINDING: Genetic variation in the NCAN gene (rs1064395) is a common risk factor for bipolar disorder and schizophrenia.
Neural Plasticity, 2014 • May 22, 2014
The review explores the link between hippocampal neurogenesis and the action of antidepressant therapies, particularly ECT. While speculations about this connection have existed for over a decade, con...
KEY FINDING: Experimental ECS enhances neurogenesis in various species. A close relationship exists between hippocampal function and mood regulation.
Top Spinal Cord Inj Rehabil, 2022 • January 1, 2022
The study investigates the feasibility of using HRV biofeedback training to reduce anxiety in adults with SCI/D, with modifications made due to the COVID-19 pandemic. The modified protocol involves re...
KEY FINDING: The modified protocol utilizes HIPAA-compliant technologies, such as Zoom, DocuSign, and a commercially available HRV sensor and smartphone application, to facilitate implementation of the intervention at home.
eClinicalMedicine, 2024 • December 1, 2024
This meta-analysis used data from the CENTER-TBI and TRACK-TBI studies to explore whether polygenic risk scores (PRS) for PTSD and major depressive disorder (MDD) are associated with the development o...
KEY FINDING: PTSD-PRS was significantly associated with higher adjusted odds of PTSD in both cohorts, with a pooled odds ratio (OR) of 1.55 [95% confidence interval (CI) 1.30–1.84, p < 0.001].
Scientific Reports, 2025 • January 1, 2025
The study investigated the role of perineuronal nets (PNNs), formed by extracellular matrix (ECM) molecules, in fear memory processes using mice lacking brevican, neurocan, tenascin-C, and tenascin-R ...
KEY FINDING: Mice lacking brevican, neurocan, tenascin-C, and tenascin-R (4x KO) exhibited impaired fear memory consolidation, indicated by their inability to retrieve previously learned fear memories.
Brain Sci., 2025 • February 14, 2025
Spinal cord injury (SCI) leads to secondary complications like gut dysbiosis (GD) and NLRP3 inflammasome activation, impacting mental health due to disrupted gut microbiome and inflammatory processes....
KEY FINDING: Gut dysbiosis (GD) and activation of the NLRP3 inflammasome are significant secondary complications after spinal cord injury (SCI), impacting mental health.
Addict Biol, 2022 • September 1, 2022
The study compared the ability of social (peer) versus nonsocial (light/tone) cues to reinstate cocaine seeking in rats and investigated the role of oxytocin (OT) neurons in the paraventricular nucleu...
KEY FINDING: Rats trained with peer cues showed reduced latency to respond during cocaine sessions compared to those trained with light/tone cues, suggesting anticipatory behavior.
Cureus, 2022 • December 23, 2022
This systematic review examined the effect of arts-based interventions on patient care in Nigeria, finding that art-based interventions have a role in healthcare delivery in Nigeria. The review includ...
KEY FINDING: In all the studies, the art-based intervention significantly improved the overall outcome of the patients.
Neurosurgery, 2023 • February 1, 2023
This systematic review examined the psychiatric impact of awake craniotomy (AC) by analyzing 24 studies involving 1450 patients. The review aimed to determine whether AC leads to increased stress, anx...
KEY FINDING: The review included 24 articles consisting of 1450 patients from 13 countries, with anxiety being the most common psychological outcome evaluated.