GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury

This study investigates how a drug called GsMTx-4, which blocks certain channels in cells, combined with exercise, affects muscle and motor function in rats with spinal cord injuries. The researchers found that the combination of GsMTx-4 and exercise led to better muscle structure and improved motor function compared to using either treatment alone. These findings suggest that this combined approach could be a more effective way to help patients recover from spinal cord injuries by improving muscle health and movement.

• 1
  The combination therapy significantly improved motor function, as measured by the Basso–Beattie–Bresnahan score and Gait Symmetry.
• 2
  Histological analysis showed that the combined treatment increased muscle fiber cross-sectional area and acetylcholinesterase levels in the soleus muscle.
• 3
  The combined treatment increased neuron counts and BDNF levels in spinal tissue while reducing TUNEL-positive cells, indicating reduced apoptosis.