Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 191-200 of 12,052 results
Materials Today Bio, 2025 • January 23, 2025
The study introduces QLipTC@HDM, a multifunctional liposome hydrogel drug delivery system, to improve quercetin delivery for spinal cord injury (SCI) treatment. The system enhances drug solubility, re...
KEY FINDING: QLipTC@HDM induces M2 phenotype transformation in glial cells and in mice with SCI, thereby mitigating inflammation.
Brain and Spine, 2025 • January 23, 2025
This study comprehensively examines the temporospatial dynamics of vascular injury and regeneration following experimental spinal cord injury (SCI) in mice, focusing on changes in vascular density, pe...
KEY FINDING: Vascular injury is most severe initially at the epicenter and spreads to surrounding spinal cord regions, with a delayed vascular loss observed in peritraumatic regions.
Molecular Neurodegeneration, 2025 • January 23, 2025
This study aimed to identify transcription factor (TF) combinations that could activate regeneration-associated genes (RAGs) and promote axon regeneration after spinal cord injury. Through in vitro sc...
KEY FINDING: Promoter analysis identified ATF3, Jun, CEBPD, KLF7, MEF2, SMAD1, SOX11, STAT3 and SRF as candidate RAG-activating TFs.
International Journal of Surgery Case Reports, 2025 • January 23, 2025
This case report presents a rare instance of urogenital myiasis in a 40-year-old male with a spinal cord injury and long-term indwelling urinary catheter, a combination not frequently reported in exis...
KEY FINDING: A 40-year-old male with a spinal cord injury developed urogenital myiasis due to long-term catheter use, presenting with maggots at the urethral meatus.
Korean J Neurotrauma, 2025 • January 23, 2025
This case report describes a 36-year-old woman who developed left-sided hemiparesis following IDET for cervical disc herniation. MRI revealed cervical cord edema, and examination showed neurological d...
KEY FINDING: The patient experienced left-sided hemiparesis after IDET, indicating neurological damage. MRI confirmed cervical cord edema.
Systematic Reviews, 2025 • January 23, 2025
This systematic review assesses the measurement properties of TBI-QoL and SCI-QoL using the COSMIN framework to guide evidence-based application. The review finds sufficient content validity, structur...
KEY FINDING: Both TBI-QoL and SCI-QoL show sufficient content, structural, internal consistency, and construct validity.
Cell & Bioscience, 2025 • January 23, 2025
This study demonstrates that trehalose enhances myelin debris clearance and reduces foamy macrophage formation after SCI by inducing TFEB expression in macrophages and modulating the autophagy-lysosom...
KEY FINDING: Trehalose enhances macrophage phagocytosis and clearance of myelin debris in a dose-dependent manner in vitro, with an optimal concentration of 20 mM.
Journal of Nanobiotechnology, 2025 • January 22, 2025
This study investigates the application of decellularized tissue matrices (DSCM) hydrogels functionalized with extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) for spinal cor...
KEY FINDING: DSCM@EVs promote NSC differentiation into neurons and suppress astrocyte formation, alleviating SCI in mice.
Molecules, 2025 • January 22, 2025
This study presents a novel MXene-reinforced composite cryogel scaffold for neural tissue regeneration, leveraging MXene's conductivity and biocompatibility within a PVA matrix. The MXene/PVA cryogel ...
KEY FINDING: The MXene/PVA cryogel is cytocompatible and supports neural cell proliferation. Embedded MXenes did not inhibit cell growth; rather, they stimulated cell proliferation by 15–44%.
Journal of Nanobiotechnology, 2025 • January 22, 2025
This study engineered a methylprednisolone substitution lipid nanoparticle (MP-LNP) encapsulating C3 transferase mRNA (MP-LNP-C3) for SCI treatment. The MP-LNP effectively transfected neurons and achi...
KEY FINDING: The incorporation of C3 transferase mRNA into MP-LNPs does not compromise the structural integrity of the nanoparticles, ensuring efficient mRNA expression within the spinal cord.