Browse the latest research summaries in the field of musculoskeletal medicine for spinal cord injury patients and caregivers.
Showing 241-250 of 278 results
Eur J Appl Physiol, 2013 • December 1, 2013
This study investigated the impact of activity-based therapy (ABT) on bone mineral density (BMD) and bone turnover in individuals with spinal cord injury (SCI). The results indicated that chronic ABT ...
KEY FINDING: Spine BMD significantly increased (+4.8%) after 6 months of ABT.
PLoS ONE, 2013 • November 22, 2013
This meta-analysis examined the effectiveness of bisphosphonates and FES in preventing bone loss following SCI. It included 19 studies with a total of 364 SCI patients and 14 healthy controls. The res...
KEY FINDING: Acute SCI patients treated with bisphosphonates showed a trend toward less bone loss compared to those receiving a placebo or usual care, with significant differences noted at 3 and 12 months post-medication.
Bone, 2014 • March 1, 2014
This study investigated the mechanical consequences of bone loss and simulated bone recovery in the proximal tibia of individuals with acute spinal cord injury (SCI). The results indicated that SCI-re...
KEY FINDING: Subjects lost 8.3% of their bone mineral density during the acute period of SCI.
PM R, 2014 • May 1, 2014
Assessment of BMD in children is challenging because of the limitations of DXA in evaluating the growing skeleton. Increasing evidence suggests that bisphosphonates may be beneficial for pediatric dis...
KEY FINDING: Data suggest short-term improvements in BMD, whereas effects on fracture risk remain an area of debate.
Indian Journal of Orthopaedics, 2014 • March 1, 2014
This prospective longitudinal study evaluated body composition changes in 95 patients with acute SCI using DEXA during the first year post-injury. The study found a marked decrease in BMC and LBM with...
KEY FINDING: There was a significant decrease in BMC (P < 0.05) and LBM (P < 0.05) and increase in total body fat mass (TBFM) and percentage fat at infra‑lesional sites.
Asian Spine Journal, 2014 • June 1, 2014
The study evaluated the clinical, radiological, and functional outcomes of patients with fresh thoracolumbar fractures treated with pedicle screw fixation and monosegmental fusion. The results indicat...
KEY FINDING: Significant improvements were observed in sagittal index and compression percentage postoperatively, with these improvements largely maintained at the one-year follow-up.
BioMed Research International, 2014 • July 20, 2014
This study examined the impact of spinal cord injury (SCI) on bone structure in rats, along with the effects of passive standing (PS) and electrical stimulation (ES) as potential interventions. The re...
KEY FINDING: SCI leads to significant reductions in bone mass and periosteal radii in rats.
Experimental & Molecular Medicine, 2021 • April 15, 2021
The study investigates the role of 4-1BB signaling in age-related bone loss in mice. It finds that 4-1BB and its ligand 4-1BBL accumulate in the bone marrow of aged mice. Upregulation of 4-1BB in bone...
KEY FINDING: 4-1BB is upregulated in BMSCs from aged mice, which leads to the attenuation of osteogenic differentiation potential via the p38 MAPK-Dkk1 pathway.
Biomedicines, 2021 • July 8, 2021
This study evaluated the efficiency of a cationic, hyperbranched poly(amidoamine)s-based nanoparticle system to deliver tdTomato mRNA to primary human bone marrow stromal cells (hBMSC), human synovial...
KEY FINDING: Transfection efficiencies varied among the cell types tested (bCH 28.4% ± 22.87, rTDSPC 18.13% ± 12.07, hBMSC 18.23% ± 14.80, hSDSC 26.63% ± 8.81).
Photoacoustics, 2021 • August 26, 2021
This study investigates the feasibility of using multi-wavelength photoacoustic (MWPA) analysis to detect collagen in bone as a biomarker for bone health assessment, focusing on the wavelength range o...
KEY FINDING: The study successfully demonstrated the feasibility of using multi-wavelength photoacoustic (MWPA) analysis for detecting collagen content in bone.