Musculoskeletal Medicine Research

KEY FINDING: Moderate evidence supports the use of pharmacology, particularly bisphosphonates, for treating bone loss after SCI.

KEY FINDING: Lower sclerostin levels were significantly associated with lower bone mineral content and bone density at all skeletal sites tested.

KEY FINDING: BMD was significantly lower in SCI patients than in controls at all femoral sites (femoral neck, total femur, and distal femur).

KEY FINDING: Sclerostin is a key mediator in SCI-induced bone loss. Initially, sclerostin levels increase after SCI due to mechanical unloading, leading to reduced bone formation.

KEY FINDING: The common injuries making neurologic deterioration were burst fracture and fracture-dislocation.

KEY FINDING: Over 1.5 years, the rate of bone mineral density (BMD) decline was slower in all quadrants of the femur for limbs undergoing active-resisted stance compared to passive stance.

KEY FINDING: High-torque and long-duration static stretching led to greater restoration of ROM than the other torque and duration treatment groups.

KEY FINDING: A handcyclist with a spinal cord injury developed intersection syndrome after a long training session involving repetitive wrist flexion and extension.

KEY FINDING: SCI reduced distal femoral and proximal tibial bone mineral density (BMD) by 25 and 16%, respectively, at 56 days.

KEY FINDING: EMS training significantly increased quadriceps femoris (QF) muscle size compared to the control group.