Musculoskeletal Medicine Research

KEY FINDING: Both ROI-C and CCP groups achieved bony fusion at the final follow-up, indicating similar efficacy in promoting spinal stability.

KEY FINDING: MSC-Exos have low immunogenicity, are more accessible, have improved preservation qualities, and potentially have low carcinogenic risks compared to MSCs.

KEY FINDING: ALDF effectively alleviates symptoms of lumbar disc herniation, with significant improvements in JOA, ODI, and NRS scores postoperatively.

KEY FINDING: TPTD significantly increased bone mineral density and other key bone indicators after SCI in rats, while ALN did not show significant improvement in these areas.

KEY FINDING: The motorized injection group had significantly fewer intraoperative X-ray fluoroscopies compared to the manual injection group, indicating reduced radiation exposure for the surgeon.

KEY FINDING: SREs occurred in 23 patients during the study period, with radiation to the bone and malignant spinal cord compression being the most frequent initial events.

KEY FINDING: Lumbar disc puncture in mice induces chronic hindpaw mechanical allodynia, hyperalgesia, grip weakness, and spontaneous pain, lasting up to 24 weeks.

KEY FINDING: Mesenchymal stem cell (MSC) exosomes participate in tissue repair and injury processes, suggesting their potential as drug carriers. Macrophage-derived exosomes can affect the tissue microenvironment by modulating immune function and tend to accumulate in cancer cells due to specific surface proteins.

KEY FINDING: Several genes (e.g., MMP12, MPEG1, CHI3L1, and CD36) were identified as potential new markers of chondrogenesis. These genes could indicate how culture conditions affect ASCs.

KEY FINDING: sCLU is associated with inflammatory responses, tissue degeneration, and cellular apoptosis during acute and subacute traumatic SCI.