Browse the latest research summaries in the field of musculoskeletal medicine for spinal cord injury patients and caregivers.
Showing 271-278 of 278 results
The American Journal of Human Genetics, 2016 • March 3, 2016
The study identifies loss-of-function mutations in TRIP4 and ASCC1, encoding subunits of the ASC-1 complex, as the cause of a syndrome characterized by prenatal SMA, congenital contractures, respirato...
KEY FINDING: Homozygous and compound heterozygous nonsense and frameshift mutations in TRIP4 and ASCC1 genes cosegregate with a disease phenotype characterized by prenatal-onset SMA and congenital bone fractures.
Orthopedic Reviews, 2016 • January 1, 2016
This study evaluated the use of bone marrow aspirate concentrate (BMAC) in conjunction with core decompression for the treatment of femoral head osteonecrosis (FHN). The trial found that while core de...
KEY FINDING: Significant pain reduction and functional improvement were observed postoperatively in both groups.
Acta Orthopaedica, 2016 • July 1, 2016
This study evaluated the effect of a single dose of erythropoietin (EPO) on bone healing in a rabbit long-bone defect model. EPO was administered either locally to the defect or systemically during su...
KEY FINDING: Both local and systemic EPO treatment significantly increased bone formation compared to the control group. Specifically, bone formation was 2.3 to 2.5 times greater in the treatment groups after 12 weeks.
The Journal of Spinal Cord Medicine, 2018 • November 1, 2018
This retrospective study analyzed 132 patients with spinal cord injury (SCI) who sustained lower extremity fractures over an 11-year period. The study aimed to identify demographic characteristics, ou...
KEY FINDING: The study identified a non-union rate of 15.9% among SCI patients with lower extremity fractures.
Annals of Translational Medicine, 2019 • October 1, 2019
This study investigates the role of HSC70 in C2C12 myoblast differentiation, finding that HSC70 is up-regulated during differentiation. The research demonstrates that HSC70 knockdown inhibits myoblast...
KEY FINDING: HSC70 expression is significantly up-regulated during C2C12 myoblast differentiation.
Therapeutics and Clinical Risk Management, 2020 • January 1, 2020
This study confirms the safety of musculoskeletal CEUS using sulfur hexafluoride contrast agent, with a lower rate of adverse events compared to other contrast agents. The study analyzed 2268 CEUS exa...
KEY FINDING: The total rate of all adverse events was 0.13%, and the rate of severe adverse events was 0.04%.
Frontiers in Endocrinology, 2020 • July 3, 2020
Osteoporosis, a chronic skeletal disorder common in older adults, leads to fractures due to decreased bone mass. Current treatments are insufficient, making stem cell therapies a promising regenerativ...
KEY FINDING: Mesenchymal stem cells (MSCs) are pivotal candidates for bone regeneration due to their anti-inflammatory and immune-privileged potential, making them ethically less concerning than other stem cell types.
Journal of Inflammation Research, 2021 • January 1, 2021
This study aimed to determine the incidence of occult infections (OI) in patients receiving autologous bone grafting (ABG) for non-union (NU) treatment, evaluate its impact on the outcome, and identif...
KEY FINDING: The incidence of occult infections after non-union treatment of the lower limb remains at 9.04% despite thorough preoperative screening.