Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 81-90 of 730 results
Journal of Nanobiotechnology, 2024 • July 3, 2024
This study investigates the therapeutic effects of iPSC-NSCs-Exos on microglia/macrophage pyroptosis in a mouse SCI model, utilizing miRNA microarray analysis and rescue experiments to confirm the rol...
KEY FINDING: IPSC-NSCs-derived exosomes can package and deliver let-7b-5p, regulating the expression of LRIG3 to ameliorate microglia/macrophage pyroptosis and enhance motor function in mice after SCI.
BMC Neuroscience, 2022 • September 1, 2022
This study investigated the impact of morphine on immune cells (microglia and macrophages) following spinal cord injury (SCI) in rats. The research aimed to understand how morphine affects the inflamm...
KEY FINDING: Morphine significantly increased the number of microglia and macrophages around the spinal cord lesion after SCI.
Journal of Neuroinflammation, 2022 • October 4, 2022
This study investigates the effect of SAFit2 on nerve injury-induced neuropathic pain in mice. The findings indicate that SAFit2 reduces neuroinflammation and ameliorates mechanical hypersensitivity. ...
KEY FINDING: SAFit2 ameliorates nerve injury-induced neuropathic pain by reducing neuroinflammation.
Frontiers in Immunology, 2022 • September 26, 2022
This study investigated the role of cannabinoid receptor-2 (CB2R) in neuroinflammation following spinal cord injury (SCI). The results showed that CB2R activation attenuated neuroinflammation by promo...
KEY FINDING: CB2R activation promotes M2 microglia differentiation, increases IL-10 expression, and inhibits M1 differentiation, decreasing IL-1b and IL-6 expression.
Brain and Behavior, 2022 • November 1, 2022
This study investigates the potential of nesfatin-1, a neuropeptide with known protective effects, as a treatment for spinal cord injury (SCI). The research demonstrates that nesfatin-1 administration...
KEY FINDING: Nesfatin-1 improved neurological recovery in SCI mice by increasing BBB scores, reducing lesion area volume, and decreasing spinal cord water content.
Frontiers in Immunology, 2022 • October 5, 2022
This study identifies and characterizes aging/senescence-induced genes (ASIGs) in osteosarcoma to predict clinical prognosis. The researchers used data from public databases to identify three molecula...
KEY FINDING: The study identified three distinct molecular subgroups of osteosarcoma based on the expression of aging/senescence-induced genes (ASIGs), each exhibiting varying levels of immune infiltration.
Cureus, 2022 • September 15, 2022
This article presents two case reports of elderly male patients who developed transverse myelitis (TM) as a complication of SARS-CoV-2 infection. Both patients experienced lower extremity weakness, se...
KEY FINDING: Both patients developed acute TM following SARS-CoV-2 infection, despite only exhibiting mild or no classic COVID-19 symptoms.
Biomedicines, 2022 • October 8, 2022
This study evaluates the efficacy of an antibiotic-loaded ceramic-based bone graft substitute (HACaS+G) for treating infected non-unions in a rat model. The results indicate that HACaS+G is osteoinduc...
KEY FINDING: HACaS+G demonstrated osteoinductive properties, stimulating bone formation in both infected and non-infected conditions.
BMC Musculoskeletal Disorders, 2022 • October 14, 2022
This study evaluates the mechanical strength of six different dual antibiotic-loaded bone cement (dALBC) preparations made from three commonly used PMMA bone cements (Copal spacem, Copal G + V, Palaco...
KEY FINDING: Copal G + V showed the highest bending strength after 24 hours, but after six weeks, the bending strength decreased in all preparations.
Frontiers in Immunology, 2022 • October 13, 2022
This study investigates the role of IRG1/itaconate in neuropathic pain, demonstrating that endogenous itaconate levels increase in the spinal cord following nerve injury. Deficiency of IRG1 exacerbate...
KEY FINDING: The levels of itaconate and IRG1 in the spinal cord significantly increased after CCI (chronic constriction nerve injury).