Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 71-80 of 730 results
Neural Plasticity, 2022 • August 29, 2022
This review explores the relationship between TSPO and chronic pain, highlighting its vital role in alleviating the initiation and maintenance of various types of chronic pain. TSPO acts as a negative...
KEY FINDING: TSPO is upregulated with microglial activation during neuroinflammation, serving as a marker and predictor of chronic pain.
Frontiers in Immunology, 2022 • August 24, 2022
This study aimed to identify key genes and pathways activated in macrophages and microglia during the subacute and chronic phases of SCI using bioinformatics analysis of the scRNA-seq dataset GSE15963...
KEY FINDING: APOE was identified as a hub gene in both macrophages and microglia during the subacute and chronic phases of SCI.
Cells, 2022 • September 8, 2022
This study investigates the neuroprotective effects of melatonin on spinal cord injury (SCI) in mice, focusing on the Nrf2/ARE/NLRP3 pathway. The results demonstrate that melatonin promotes neuromotor...
KEY FINDING: Melatonin promotes the recovery of neuromotor function by inhibiting neuroinflammation and reducing neuronal death.
Antioxidants, 2022 • August 23, 2022
This study investigates the role of LRRK2 inhibition by PF06447475 (PF-475) in modulating early neuronal damage after spinal cord trauma (SCI) in mice. The results show that PF-475 treatments, particu...
KEY FINDING: PF-475 treatments reduced the degree of spinal cord tissue injury, glycogen accumulation, and demyelination associated with trauma.
Journal of Pain Research, 2022 • September 13, 2022
This study investigates the effects of differential target multiplexed spinal cord stimulation (DTMP) and traditional low-rate spinal cord stimulation (LR-SCS) on the mTOR pathway in a neuropathic pai...
KEY FINDING: DTMP and LR-SCS reverse injury-induced changes of the mTOR pathway while treating neuropathic pain.
The Journal of Spinal Cord Medicine, 2022 • January 1, 2022
The case report presents a unique instance of a patient developing acute cerebellitis, transverse myelitis, and Guillain-Barré syndrome (GBS) following a COVID-19 infection. Neurological examination a...
KEY FINDING: A 42-year-old male developed cerebellitis, transverse myelitis, and GBS two weeks after a COVID-19 infection.
Frontiers in Bioengineering and Biotechnology, 2022 • September 15, 2022
The study successfully fabricated FA-PEG/ZIF-8 nanoparticles, demonstrating their potential to restore function in vivo by selectively eliminating pro-inflammatory microglia/macrophages (M/Ms) without...
KEY FINDING: FA-PEG/ZIF-8 treatment significantly eliminated pro-inflammatory M/Ms in vivo without targeting other nerve cells and downregulated inflammation in the injured lesion.
Journal of Neuroinflammation, 2022 • January 1, 2022
This review discusses the role of STING signaling in CNS injury, highlighting its involvement in inflammation, autophagy, necroptosis, ferroptosis, and pyroptosis. The cGAS–STING pathway is a key regu...
KEY FINDING: STING signalling is markedly increased in CNS injury, and STING agonists might facilitate the pathogenesis of CNS injury.
Curr Opin Pharmacol, 2022 • December 1, 2022
Chronic SCI results in systemic inflammation, immunosuppression, and multiple organ dysfunction, leading to exacerbated maladaptive responses and increased morbidity and mortality due to chronically a...
KEY FINDING: Chronic SCI is associated with elevated levels of CRP, a clinical marker of systemic inflammation and cardiovascular disease risk.
Frontiers in Neuroscience, 2022 • September 20, 2022
This systematic review investigated the neuroinflammatory effects of PBM therapy in animal models of brain pathological conditions. The reviewed studies showed that the therapeutic effects of transcra...
KEY FINDING: PBM reduces pro-inflammatory cytokines and microglia activation in traumatic brain injury animal models.