Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 61-70 of 730 results
Bioelectronic Medicine, 2025 • March 6, 2025
The study investigated the effects of low-intensity trans-spinal focused ultrasound (tsFUS) on neuropathic pain in rats with chronic constriction injury (CCI). tsFUS was applied to the L5 spinal segme...
KEY FINDING: tsFUS treatment increased the von Frey threshold (vFT) in rats with CCI compared to sham treatment, indicating reduced mechanical sensitivity. This effect persisted for up to 23 days post-CCI.
The Journal of Spinal Cord Medicine, 2022 • November 1, 2022
This case report describes the successful treatment of pyocystis with a single amikacin bladder instillation in a 59-year-old male with paraplegia and anuria. The patient, who had recurrent episodes o...
KEY FINDING: A single-dose intravesical instillation of amikacin 25 mg/100 mL successfully treated pyocystis in an anuric SCI patient with recurrent autonomic dysreflexia.
Archives of Orthopaedic and Trauma Surgery, 2022 • December 1, 2021
The study evaluates a custom-made articulating hip spacer for two-stage revision in periprosthetic joint infections, focusing on complication rates, infection control, implant survivorship, and patien...
KEY FINDING: Infection control was achieved in 96% of patients after reimplantation, with an implant survivorship of 92% after a mean follow-up time of 19 months.
Cancer Immunology, Immunotherapy, 2022 • January 27, 2022
This study used single-cell RNA sequencing to map the transcriptomic landscape of chordomas, revealing significant intratumoral heterogeneity and potential therapeutic targets. The analysis identified...
KEY FINDING: Chordoma tumors exhibit significant intratumoral heterogeneity, with distinct subpopulations of chordoma cells, fibroblasts, and immune cells.
The Journal of Spinal Cord Medicine, 2024 • January 1, 2024
This study investigated the potential of tropisetron, an α7nAChR agonist, to alleviate neuropathic pain and neuroinflammation in rats with spared nerve injury (SNI). The results demonstrated that trop...
KEY FINDING: Tropisetron effectively alleviated mechanical allodynia and thermal hyperalgesia in rats with spared nerve injury (SNI).
Neurotherapeutics, 2022 • May 2, 2022
This study investigates the efficacy of dual HDAC/BRD4 inhibitors, SUM52 and SUM35, in treating neuropathic pain using a spared nerve injury (SNI) model in mice. The results indicate that both SUM52 a...
KEY FINDING: SUM52 and SUM35, administered intranasally, reduced thermal and mechanical hypersensitivity in mice with spared nerve injury (SNI), a model of neuropathic pain.
CNS Neurosci Ther, 2024 • June 25, 2024
The study established NMOSD animal models in both aged and young mice using the EAE model, observing a higher disease incidence and elevated clinical scores compared to the EAE model alone. GV-971 tre...
KEY FINDING: GV-971 significantly reduces the incidence of NMOSD, alleviates symptoms, and prolongs survival in NMOSD mouse models.
Neural Regen Res, 2023 • February 1, 2023
Accumulating evidence has proven that acute SCI and TBI can cause a secondary injury by several bioprocesses. cPLA2, the heavyweight component of cellular signal transduction in inflammatory responses...
KEY FINDING: cPLA2 is vital for the production of diverse inflammatory mediators: a variety of inflammatory mediators are directly or indirectly involved in the pathogenesis of CNS trauma
Pain, 2023 • February 1, 2023
This study investigated the role of pronociceptive autoimmune responses in the spinal cord in mediating pain behaviors, functional loss, and spontaneous pain in a lumbar disc puncture model of low bac...
KEY FINDING: Lumbar disc puncture in mice induces chronic hindpaw mechanical allodynia, hyperalgesia, grip weakness, and spontaneous pain, lasting up to 24 weeks.
Journal of Neuroinflammation, 2022 • September 1, 2022
This study investigates the potential of human placental mesenchymal stem cell-derived small extracellular vesicles (hPMSCs-derived sEVs) to alleviate neuropathic pain in a spared nerve injury (SNI) m...
KEY FINDING: A single intrathecal injection of sEVs durably reversed mechanical hypersensitivity in the left hind paw of mice with partial sciatic nerve ligation.