Immunology Research

KEY FINDING: A 40-year-old male with a spinal cord injury developed urogenital myiasis due to long-term catheter use, presenting with maggots at the urethral meatus.

KEY FINDING: Efgartigimod, an FcRn blocker, alleviated mechanical allodynia when administered either 7 or 28 days post-CCI.

KEY FINDING: X-SCID rats exhibited significantly higher retention of transplanted NPCs compared to both Wistar and RNU rats, indicating that both T and B cells play crucial roles in the rejection of xenografted human NPCs.

KEY FINDING: The modified PVCR technique resulted in a significant improvement in kyphosis angle (KA) from 129.5° to 43.7° postoperatively.

KEY FINDING: The combination of Shinbaro and celecoxib synergistically reduced mechanical hyperalgesia and paw edema in mice with CFA-induced inflammatory pain.

KEY FINDING: A total of 522 DEGs were filtered. Enrichment analysis of their biological functions and pathways yielded the most closely related results for inflammatory response, regulation of cytokine production, neutrophil chemotaxis and degranulation, angiogenesis, cell death, TNF signaling pathway, and osteoclast differentiation.

KEY FINDING: SCI significantly increased FL2 expression in the lesion site and rostral to the lesion at 1 day post-injury.

KEY FINDING: EA treatment significantly alleviated pain hypersensitivity by increasing the MWT and PWL in CCI rats.

KEY FINDING: Topical application of isomerized potassium linoleate (KCLA) rapidly reduced tenderness in the forearm supinator muscle within 2-4 minutes.

KEY FINDING: ISRIB suppresses neuron death and neuroinflammation following SCI.