Immunology Research

KEY FINDING: Spatiotemporal dynamic neuroinflammation plays an important role in secondary injury after SCI. Inflammatory cells and mediators have different roles at different stages of inflammation.

KEY FINDING: Most studies used inbred, young adult, male mice with peripheral nerve injury, limiting the generalizability of the data.

KEY FINDING: The study highlights a rare case of cervical spine pyogenic infection (CSPI) stemming from chronic paronychia, emphasizing that infections can originate from unexpected sources.

KEY FINDING: MOA treatment improved locomotor scores and reduced residual urine volume in rats after SCI, indicating improved motor and bladder function.

KEY FINDING: EJCDs promote HSC self-renewal and erythroid differentiation in the bone marrow by upregulating FZD4 protein expression in LSK cells.

KEY FINDING: The combination of ceftriaxone and ADMSCs resulted in significantly lower levels of TNF-α and IL-6 in both circulatory and spinal cord fluid compared to ceftriaxone or ADMSCs alone, indicating a stronger anti-inflammatory effect.

KEY FINDING: SIX1 expression increases in microglia following SCI in mice and is positively correlated with the M1 microglia marker iNOS and negatively correlated with the M2 microglia marker Arg1.

KEY FINDING: The researchers successfully developed and characterized five humanized anti-CD11d monoclonal antibodies.

KEY FINDING: Patients with SCI treated with MTX had higher infection rates compared to those treated with biologics.

KEY FINDING: The spatial dynamics of immune cells following SCI are crucial for understanding their mechanisms in neuroinflammation and repair, and for developing new therapies.