Rapid Reversal of Forearm Supinator Rigidity With Topical Isomerized Potassium Linoleate: A Novel Perspective on Microbiome-Induced Tetany

Cureus, 2025 · DOI: 10.7759/cureus.80896 · Published: March 20, 2025

Simple Explanation

The study explores the connection between microbes and neurological function, particularly focusing on rigidity or tetany in the forearm. Five patients with vertigo of central origin and forearm rigidity were treated with a topical cleanser containing isomerized potassium linoleate (KCLA). The application of KCLA led to a rapid resolution of tenderness and improved wrist rotation, suggesting the skin microbiome may contribute to clinical tetany.

Study Duration

Not specified

Participants

Five patients diagnosed with vertigo of central origin

Evidence Level

Case Series

Key Findings

1
Topical application of isomerized potassium linoleate (KCLA) rapidly reduced tenderness in the forearm supinator muscle within 2-4 minutes.
2
Extended wrist rotation improved toward the norm within 3-10 minutes after KCLA application (p < 0.01), and the improvement lasted beyond the clinic visit.
3
The rapid response suggests the commensal skin biome may contribute to clinical tetany in the forearm supinator.

Research Summary

This case series investigates the rapid reversal of forearm supinator rigidity using topical isomerized potassium linoleate (KCLA) in five patients diagnosed with vertigo of central origin. The study found that topical application of KCLA led to a rapid reduction in tenderness and improvement in wrist rotation, suggesting a potential link between the skin microbiome and clinical tetany. The authors conclude that these findings warrant further exploration of topical isomerized KCLA as a means to reduce clinical rigidity, opening new avenues for research into microbiome-related neurological conditions.

Practical Implications

Potential Therapeutic Intervention

Topical KCLA may offer a novel, rapid-acting treatment for rigidity and tetany associated with certain conditions.

Microbiome-Neurological Connection

The study highlights the potential role of the skin microbiome in influencing neurological function and muscle tone.

Parkinsonism and Trauma

The findings suggest a possible link between traumatic brain injuries, microbiome alterations, and the development of Parkinsonism symptoms, warranting further investigation.

Study Limitations

1
Lack of microbiological support to directly link observed clinical supinator tetany to a change in commensal behavior in the skin.
2
The reversal of tetany with topical KCLA application does not definitively prove the skin's microbiome contributes to rigidity or tetany.
3
The study does not limit or imply applicability beyond this patient population.

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