Effects of Combined Shinbaro and Celecoxib in a Complete Freund’s Adjuvant-Induced Inflammatory Pain Mouse Model

This study investigated whether combining Shinbaro (an herbal medicine) and celecoxib (an anti-inflammatory drug) could enhance pain relief in mice with induced inflammatory pain. The researchers modeled inflammatory pain in mice by injecting a substance called CFA into their paw. The results showed that the combination was more effective than either treatment alone in reducing pain and swelling. The combined treatment also decreased inflammatory cells in the affected area and reduced the activity of cells in the spinal cord that contribute to ongoing pain. These findings suggest that this combination could be a more potent approach to treating inflammatory pain, potentially allowing for lower doses of celecoxib and reducing the risk of side effects.

• 1
  The combination of Shinbaro and celecoxib synergistically reduced mechanical hyperalgesia and paw edema in mice with CFA-induced inflammatory pain.
• 2
  The combination therapy attenuated the infiltration of macrophages into the hind paw, which is associated with reduced inflammation.
• 3
  The combined treatment inhibited the activation of microglia and astrocytes in the spinal cord, reducing the expression of pro-inflammatory cytokines and mediators.