Immunology Research

KEY FINDING: Exercise regimens can reduce the severity of clinical manifestations of EAE, including neurological signs, motor function, pain, and cognitive deficits.

KEY FINDING: Transplantation of NgR(310)ecto-Fc-transduced HSCs into EAE mice resulted in significantly reduced clinical scores after the peak stage of disease symptoms, indicating recovery from neurological decline.

KEY FINDING: Cholesterol crystals accumulate in spinal cord lesions of young adult mice as early as 7 days post-injury, persisting for at least 6 weeks.

KEY FINDING: High-intensity swimming (HIS), but not low-intensity swimming (LIS), significantly alleviated mechanical and thermal hyperalgesia in CPIP mice.

KEY FINDING: Gene therapy can provide long-term sustained expression of therapeutic genes to modulate the inflammatory response after SCI, with viral vectors like lentivirus and adeno-associated virus being less immunogenic than adenovirus.

KEY FINDING: Neutrophils are involved in both detrimental and beneficial processes in the CNS and PNS, impacting conditions such as stroke, Alzheimer's disease, multiple sclerosis, and spinal cord injury.

KEY FINDING: PLGA-miR+Sp and PLGA-miR+PEI formulations were found to be significant in their immunomodulatory effects compared to naked PLGA-based NPs.

KEY FINDING: Combined therapy of RvD1 and PNSC spheroids outperformed monotherapies, exhibiting enhanced neuronal regeneration and anti-inflammatory effects.

KEY FINDING: P2RY12 deficiency protects mice from ConA-induced immune hepatitis by reducing serum ALT and AST levels, blocking the increases of serum IFN-γ, IL-12p70, IL-6, and TNF-α, and decreasing serum IL-10.

KEY FINDING: Macrophages proliferate in various organs and tissues, including skin, peritoneum, lung, heart, aorta, kidney, liver, pancreas, brain, spinal cord, eye, adipose tissue, and uterus, and in different species including mouse, rat, rabbit, and human.