Co-Administration of Resolvin D1 and Peripheral Nerve-Derived Stem Cell Spheroids as a Therapeutic Strategy in a Rat Model of Spinal Cord Injury

This study investigates a new approach to treat spinal cord injuries (SCI) in rats, combining resolvin D1 (RvD1), an anti-inflammatory substance, with stem cells from peripheral nerves (PNSC spheroids). The researchers found that this combination therapy led to better recovery in rats with SCI compared to using either treatment alone. The combined treatment reduced inflammation and helped regenerate nerve tissue. These findings suggest that using RvD1 and PNSC spheroids together could be a promising new way to manage SCI, promoting healing and restoring function.

• 1
  Combined therapy of RvD1 and PNSC spheroids outperformed monotherapies, exhibiting enhanced neuronal regeneration and anti-inflammatory effects.
• 2
  The SCI/RvD1+PNSC group exhibited an increase in the total cord, myelinated, and gray matter areas, along with a significant reduction in the cavity area compared to the other groups.
• 3
  The SCI/RvD1+PNSC group showed an improvement in mechanical allodynia, approaching sham group levels at 8 weeks after SCI.