Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 551-560 of 730 results
Cell Death and Disease, 2023 • September 5, 2023
This study investigates the role of chemokine receptor CXCR1 in inflammation-inducing experimental autoimmune encephalomyelitis (EAE) and acute respiratory distress syndrome (ARDS). The study reveals ...
KEY FINDING: CXCR1 was found to be upregulated in MS patients, and its deficiency ameliorated disease severity in EAE mice by suppressing inflammatory factor secretion.
Frontiers in Immunology, 2023 • September 8, 2023
This study comprehensively analyzed gene expression in patients with PSID after major abdominal surgery to identify hub genes associated with immune and metabolic alterations. The analysis revealed si...
KEY FINDING: Identified 512 upregulated and 254 downregulated DEGs in patients with PSID compared with controls, significantly associated with immune- and metabolism-related biological processes and pathways.
Frontiers in Surgery, 2023 • September 11, 2023
Failed fracture healing remains a significant complication, and ongoing research aims to improve understanding of contributing factors at local and systemic levels. The immune system's role in bone he...
KEY FINDING: Interferon-gamma (IFN-y) signaling plays a key role in orchestrating immunological functions and serves an anabolic function in osseous biology, leading to osteoblastic activation.
Microbiology Spectrum, 2023 • September 28, 2023
This study uses bibliometric analysis to summarize research trends and hotspots in the field of gut microbiota and the immune microenvironment from 1976 to 2022, using data from the Web of Science Cor...
KEY FINDING: The annual number of publications related to gut microbiota and the immune microenvironment has increased gradually, reflecting the growing interest and development in this field.
Int. J. Mol. Sci., 2023 • September 27, 2023
This study investigates the neuroprotective activity of SUN11602, a bFGF-like compound, in modulating tissue regeneration, neuroinflammation, and Ca2+ overload using a subacute mouse model of SCI. SUN...
KEY FINDING: SUN11602 treatment significantly decreased motor alteration and diminished the neuroinflammatory state through the regulation of glial activation, the NF-κB pathway, and kinases.
Nutrients, 2023 • September 27, 2023
This study investigates the impact of recombinant Interleukin-13 (rIL-13) treatment on gut microbiota composition and functional recovery in mice after spinal cord injury (SCI). The research found tha...
KEY FINDING: Hemisection SCI disturbs the homeostatic microbiota composition.
Heliyon, 2023 • October 13, 2023
The study demonstrated that intravenously administered RIPCs significantly improved neuropathic pain symptoms, specifically thermal hyperalgesia and mechanical allodynia, in rats with partial sciatic ...
KEY FINDING: Intravenous administration of RIPCs was most effective in reducing thermal hyperalgesia and mechanical allodynia in rats with neuropathic pain.
Neural Regeneration Research, 2024 • May 1, 2024
This study demonstrated that treatment with CM containing the human DPSC-derived secretome improves functional recovery in a rat model of contusive SCI. This therapeutic effect of DPSC-CM was associat...
KEY FINDING: DPSC-CM effectively promoted the recovery of sensory and motor functions in rats with spinal cord injury.
Journal of Neuroinflammation, 2023 • October 10, 2023
This study reveals two novel normally occurring CD47-dependent mechanisms that impede myelin debris clearance by acting as a cell surface receptor. First, CD47 on Schwann cells inhibits myelin disrupt...
KEY FINDING: Myelin debris clearance, axon regeneration, and function recovery were all faster in CD47−/− mice than in wild type mice.
Journal of Neuroinflammation, 2023 • October 18, 2023
This study investigates the role of UTX in regulating BSCB permeability following SCI. The findings reveal that conditional ablation of UTX in ECs reduces vascular permeability and enhances neurologic...
KEY FINDING: Conditional UTX deletion in endothelial cells reduces BSCB permeability, decreases inflammatory cell infiltration and ROS production, and improves neurological function recovery after SCI.