Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 531-540 of 730 results
CNS Neuroscience & Therapeutics, 2023 • February 24, 2023
This study investigates the interaction between regulatory T cells (Tregs) and microglia after spinal cord injury (SCI) and how Tregs modulate the injured microenvironment. The results suggest that Tr...
KEY FINDING: Regulatory T cells infiltration of the spinal cord peaked on day 7 after SCI.
BMC Medical Genomics, 2023 • March 1, 2023
This study investigated the role of immune cell infiltration in the hippocampus of Alzheimer's disease (AD) patients and identified key genes associated with AD pathogenesis. Transcriptomic data analy...
KEY FINDING: The relative abundance of immune cells in the hippocampus of AD patients was altered compared to healthy individuals.
Bioeng Transl Med, 2023 • March 1, 2023
The review discusses the complex neuroinflammatory response after spinal cord injury (SCI), which involves both tissue damage and reparative processes. It highlights the imbalance of immune cells and ...
KEY FINDING: Neuroinflammation after spinal cord injury involves a complex interplay of immune cells, cytokines, chemokines, and neurotrophic factors, leading to both tissue damage and repair.
Cells, 2023 • March 8, 2023
The study investigates a composite implant of fibrin and carbon microfibers (MFs) to modulate post-traumatic inflammation after spinal cord injury (SCI) in a rodent model. Intravital imaging and spina...
KEY FINDING: Fibrin alone initially shows biocompatibility but later triggers chronic microglial activation and axonal degeneration.
J Clin Invest, 2023 • May 15, 2023
The study investigates the role of the C3a/C3aR axis in regulating glial responses in the peri-infarct cortex of mice subjected to ischemic stroke, assessing functional recovery and connectivity chang...
KEY FINDING: C3aR signaling has opposing effects on functional recovery after ischemic stroke: inhibition in the acute phase and facilitation in the later phase.
CNS Neuroscience & Therapeutics, 2023 • January 1, 2023
The study demonstrates that TBK1-mediated innate immune responses play an important role in the activation of reactive astrocytes after SCI. Inhibition of TBK1 promotes the activation of noncanonical ...
KEY FINDING: TBK1 and TBK1-medicated innate immune pathways were activated in astrocytes and neurons after SCI.
Frontiers in Molecular Neuroscience, 2023 • March 23, 2023
The perspective is that targeting microglial ATF3 upregulation can mitigate inflammation, representing an unexplored therapeutic approach for various CNS diseases. Small molecules can induce ATF3 expr...
KEY FINDING: ATF3 functions as a negative regulator of innate immune activation, suppressing pro-inflammatory gene expression in macrophages following TLR4 activation.
Int. J. Mol. Sci., 2023 • March 30, 2023
This review underscores the critical role of macrophages and their subpopulations in tissue repair and regeneration, focusing on their secretion of TNF-α, which promotes axonal regeneration in zebrafis...
KEY FINDING: Macrophages and their subpopulations play a crucial role in tissue repair and regeneration, focusing on their secretion of TNF-α, which promotes axonal regeneration in zebrafish.
Frontiers in Immunology, 2023 • March 29, 2023
This study investigates the role of QPCTL in glioma, finding its expression elevated in tumor tissues and associated with poor prognosis. Bioinformatic analyses reveal QPCTL's involvement in cytokine ...
KEY FINDING: QPCTL expression is higher in glioma tumor tissue compared to normal tissue, and higher expression correlates with high-grade malignancy and advanced tumor stage.
Journal of International Medical Research, 2023 • April 1, 2023
This case report details the successful emergency surgical management of a thoracic spinal epidural abscess (SEA) in a man in his early 40s who presented with acute lower limb paralysis. The patient u...
KEY FINDING: Timely diagnosis and surgical intervention within 24 hours of paralysis are crucial for recovering lower limb muscle strength in thoracic SEA cases.