Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 31-40 of 730 results
Brain and Behavior, 2014 • January 1, 2014
This study investigates the impact of pregabalin on experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS). The research focuses on how pregabalin affects synapti...
KEY FINDING: Pregabalin treatment delayed the onset of EAE, as evidenced by statistical differences at days 10 and 16 after immunization.
Nat Rev Neurol, 2015 • January 1, 2015
Microglia/macrophages are double-edged swords in the battle for neurological recovery. On the one hand, microglia/macrophage activation fosters brain recovery by clearing cell debris, resolving local ...
KEY FINDING: Microglia/macrophages exhibit a dynamic shift in phenotype after CNS injury, with an initial M2-dominant phase followed by a later M1-dominant phase.
Neural Regeneration Research, 2014 • October 1, 2014
Spinal cord injury (SCI) is a devastating type of neurological trauma with limited therapeutic opportunities. The pathophysiology of SCI involves primary and secondary mechanisms of injury. Among all ...
KEY FINDING: Inflammation, mediated by activated microglia/macrophages, plays an important role in the clearance of damaged and degenerating tissues following SCI.
Mol Cell Neurosci, 2015 • January 1, 2015
This study investigates the expression and cellular localization of Gal1 after spinal cord injury (SCI) in rats. The researchers found that Gal1 mRNA and protein levels increase significantly in the l...
KEY FINDING: Gal1 mRNA and protein expression are significantly increased in the lesion epicenter during the first week post-SCI.
International Journal of Surgery, 2025 • June 24, 2024
This prospective, double-blind, randomized controlled study evaluated the safety and efficacy of intrawound vancomycin powder in preventing surgical site infections (SSIs) after posterior lumbar inter...
KEY FINDING: The study found an 87.5% decrease in the surgical site infection (SSI) rate in the vancomycin group compared to the control group.
Neural Regeneration Research, 2025 • July 29, 2024
This review examines the therapeutic strategies targeting the C–C motif chemokine ligand 2/C–C motif chemokine receptor 2 axis, along with the regenerative and repair mechanisms linking the axis to sp...
KEY FINDING: The CCL2/CCR2 axis recruits immune cells to the injury site, stimulating microglia and macrophages, which exacerbates the inflammatory response and nerve damage, worsening SCI.
Eur J Neurol, 2024 • August 4, 2024
This study investigates noncompressive myelopathy as a rare but severe complication of community-acquired bacterial meningitis, identifying seven cases from a nationwide cohort and reviewing 15 additi...
KEY FINDING: Noncompressive myelopathy was reported in 0.23% of community-acquired bacterial meningitis cases.
IBRO Neuroscience Reports, 2024 • September 21, 2024
The study identifies seven early signature genes of SCI (ARG1, RETN, BPI, GGH, CCNB1, HIST1H2AC, and HIST1H2BJ) through bioinformatics analysis and experimental validation. Immune cell infiltration an...
KEY FINDING: Seven signature genes (ARG1, RETN, BPI, GGH, CCNB1, HIST1H2AC, and HIST1H2BJ) were identified as potential biomarkers for early SCI diagnosis.
Journal of Cellular and Molecular Medicine, 2024 • November 26, 2024
This study investigated the protective effects of quercetin, a compound found in the Chinese herbal formula Jisuikang (JSK), on spinal cord injury (SCI). The research used network pharmacology to iden...
KEY FINDING: Quercetin, a key ingredient in Jisuikang (JSK), protects microglial cells from LPS-induced inhibition of cell viability and cellular inflammation.
International Journal of Nanomedicine, 2024 • December 12, 2024
This review discusses the potential of polymeric nanoparticles (NPs) as therapeutic agents for spinal cord injury (SCI), focusing on their immunomodulatory properties. The review emphasizes how the ph...
KEY FINDING: The size of NPs affects how they are taken up by cells, influencing the immune response. Smaller NPs tend to be internalized through different pathways than larger NPs.