Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 161-170 of 730 results
BMJ Case Rep, 2023 • September 9, 2023
The report describes a case of Brown-Séquard syndrome (BSS) in an adult male with a recent COVID-19 infection. The patient's neurological symptoms rapidly improved after treatment with high-dose methy...
KEY FINDING: The patient presented with right hemiparesis and left-sided paresthesia during an active COVID-19 infection, confirmed by PCR.
Front. Pain Res., 2023 • September 22, 2023
This review provides an overview of neuropathic pain, its causes, mechanisms, and potential treatments. It highlights the limitations of current animal models and the need for improved translational a...
KEY FINDING: Peripheral nerve injury leads to the release of primary inflammatory mediators, activating immunocompetent cells and causing neuroinflammation.
Heliyon, 2023 • October 4, 2023
This study investigates the efficacy and mechanism of Wuzi Yanzong Pill (WYP) in treating experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS). The results demo...
KEY FINDING: WYP treatment significantly improved the clinical scores of EAE mice in a dose-dependent manner, indicating an improvement in neurological symptoms.
Exp Neurol, 2024 • February 1, 2024
This study investigates the immunomodulatory effects of azithromycin on hemoglobin (Hgb)-induced inflammation in microglia, both in vitro and in a rat model of neonatal intraventricular hemorrhage (IV...
KEY FINDING: Hgb induces a pro-inflammatory response in microglia, increasing ROS production, cytotoxicity, and altering mitochondrial function.
Journal of Translational Medicine, 2023 • November 15, 2023
This study demonstrates that orally administered LbGp can improve the inflammatory microenvironment in SCI and promote spinal cord repair by inhibiting the MAPK-NF-κB/pyroptosis-related pathways. LbGp...
KEY FINDING: LbGp treatment could improve the motor function of rats after SCI, with the BBB motor function score of the LbGp intervention group being higher than that of the SCI group on day 14.
Scientific Reports, 2023 • November 2, 2023
The results of this study showed that resveratrol treatment can promote the recovery of SCI in rat contusion models by inhibiting the activation of the JNK/p38MAPK signaling pathway. Resveratrol treat...
KEY FINDING: Resveratrol dramatically improved the hindlimb locomotor function and their electrophysiological outcomes.
J Surg Res, 2024 • March 1, 2024
The study presents a rat osteomyocutaneous flap model for VCA that mimics clinical rejection patterns through titrated tacrolimus administration. The model allows for the study of acute rejection, chr...
KEY FINDING: Transient immunosuppression resulted in severe acute cellular rejection within two weeks of tacrolimus discontinuation, mimicking non-compliance situations.
Molecular Pain, 2023 • November 10, 2023
The study investigates the role of HDAC6 in neuropathic pain (NP) induced by chronic constriction injury (CCI) in mice, finding that HDAC6 expression is upregulated in the spinal cord following CCI. T...
KEY FINDING: HDAC6 expression is upregulated in the spinal cord following chronic constriction injury (CCI).
Curr. Issues Mol. Biol., 2023 • October 25, 2023
Neuroinflammation significantly impacts stroke and spinal cord injury, affecting their pathophysiology, progression, and resolution by involving oxidative stress, damage, and cell death. Diagnosis inv...
KEY FINDING: Neuroinflammation plays a critical role in the pathophysiology of stroke and spinal cord injury, affecting motor function.
Science Advances, 2023 • November 24, 2023
This study investigates the role of microRNAs (miRNAs) in regulating neuronal responses to inflammation in the context of multiple sclerosis (MS) using the experimental autoimmune encephalomyelitis (E...
KEY FINDING: miR-92a is robustly induced in inflamed spinal cord neurons in mice undergoing experimental autoimmune encephalomyelitis (EAE).