Immunology Research

KEY FINDING: Inflammation and immune mechanisms after PEEK implantation lead to fibrous capsule formation, which impairs osseointegration.

KEY FINDING: A 79-year-old home-dwelling female with a history of immobility due to a spinal fracture, long-term catheterization, and constipation developed purple urine bag syndrome.

KEY FINDING: Sp treatment worsened clinical measures (increased clinical disability score, decreased body weight, and reduced rotarod retention time) in TMEV-induced mice.

KEY FINDING: Postoperative CRP and ESR were significantly lower than preoperative levels, indicating reduced inflammation.

KEY FINDING: Patients with decubitus-related osteomyelitis who did not undergo myocutaneous flapping had high rates of hospital readmission.

KEY FINDING: Gut dysbiosis in SCI patients profoundly influences multiple organs and systems, potentially leading to metabolic syndrome, inflammatory bowel disease, and depression.

KEY FINDING: Intrathecal delivery of activated Tregs reduced mechanical pain hypersensitivity and improved exploratory behaviors in both male and female mice following chronic constriction injury (CCI) of the sciatic nerve.

KEY FINDING: Various cell types like Schwann cells, olfactory ensheathing cells (OECs), and mesenchymal stem cells (BMSCs) can modulate inflammation after SCI, promoting neuroprotection and regeneration in animal models.

KEY FINDING: Research in immunology for SCI has shifted toward “extracellular vesicles,” “regenerative medicine,” “stromal cells,” “motor recovery,” and “glial activation” as new directions for investigation.

KEY FINDING: A patient with a complete SCI (ASIA A) of over four weeks duration improved two ASIA grades after antibiotic treatment and surgical decompression.